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Alomone Labs, LTD
Neurokinin 1 Receptor (NK1R) (extracellular) Polyclonal Antibody, Atto™ 488
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Neurokinin 1 Receptor (NK1R) (extracellular) Antibody (ATR-001-AG-50UL) in IHC (P)
Multiplex staining ofNK1Receptor and mGluR5 in rat DRG - Immunohistochemical staining of rat dorsal root ganglion using Anti-Neurokinin 1 Receptor (NK1R) (extracellular)-ATTO Fluor-488 Antibody (#ATR-001-AG), (green), (1:60) and Anti-mGluR5 (extracellular)-ATTO Fluor-594 Antibody (#AGC-007-AR), (red), (1:60). A. NK1 receptorstaining. B. mGluR5 staining appears in both cells (horizontal arrow) and fibers (ve... View More
产品信息
ATR-001-AG-50UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CMIEWPEHPNRTYEK, corresponding to amino acid residues 180-194 of rat NK1receptor, 2nd extracellular loop
偶联物
激发/发射光谱
501/523 nm
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Tachykinin Receptor 1, a member of the Tachykinin Receptor subfamily, is involved in the mediation of phosphatidylinositol metabolism by the tachykinin substance P, also referred to as neurokinin 1. It is associated with the management of depression, anxiety, and stress. It is also involved in regulating behavioral responses, neuronal survival, and cardiovascular and respiratory functions. The tachykinin receptor 1 is implicated in the progression of rheumatoid arthritis and osteoarthritis. Two variants of the tachykinin receptor 1 are produced by alternative splicing. Tachykinin receptor 1 has been reported primarily in brain, and in blood lymphocytes, nose, small intestine, and stomach. ESTs have been isolated from brain and spleen libraries.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: neurokinin 1 receptor; neurokinin receptor 1; NK-1 receptor; NK-1R; Nk1 receptor; SPR; substance P receptor; Substance-P receptor; Tachykinin receptor 1; tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
基因别名: NK1R; NKIR; SPR; TAC1R; TACR1
UniProt ID: (Human) P25103, (Mouse) P30548, (Rat) P14600
Entrez Gene ID: (Human) 6869, (Mouse) 21336, (Rat) 24807
aggressive behavior
acute inflammatory response
positive regulation of leukocyte migration
angiotensin-mediated drinking behavior
inflammatory response
cell surface receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
tachykinin receptor signaling pathway
chemical synaptic transmission
long-term memory
associative learning
response to heat
detection of abiotic stimulus
response to ozone
positive regulation of epithelial cell migration
response to auditory stimulus
regulation of smooth muscle cell migration
sensory perception of pain
positive regulation of synaptic transmission, cholinergic
positive regulation of synaptic transmission, GABAergic
response to estradiol
response to progesterone
response to nicotine
operant conditioning
positive regulation of renal sodium excretion
sperm ejaculation
eating behavior
positive regulation of vascular permeability
response to morphine
response to ethanol
positive regulation of action potential
positive regulation of blood pressure
positive regulation of ossification
positive regulation of vasoconstriction
positive regulation of smooth muscle contraction
positive regulation of saliva secretion
positive regulation of hormone secretion
behavioral response to pain
regulation of smooth muscle cell proliferation
positive regulation of lymphocyte proliferation
positive regulation of epithelial cell proliferation
positive regulation of stress fiber assembly
response to electrical stimulus
smooth muscle contraction involved in micturition
positive regulation of uterine smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
learning or memory
regulation of blood pressure
response to hormone
response to organic cyclic compound
response to pain
