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Neuropilin 2 Antibody (PA5-47274) in IHC (P)
Immunohistochemical analysis of Neuropilin 2 in immersion fixed paraffin-embedded sections of human pancreatic cancer tissue. Samples were incubated in Neuropilin 2 polyclonal antibody (Product # PA5-47274) using a dilution of 5 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-basic. Tissue was staine... View More
产品信息
PA5-47274
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant human Neuropilin-2 Gln23-Tyr855
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2610178
产品详细信息
In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse Neuropilin-2 is observed, and approximately 25% cross-reactivity with recombinant rat (rr) Neuropilin-2 is observed and less than 5% cross-reactivity with rrNeuropilin-1 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
靶标信息
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C) and SEMA3F protein (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F), and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Neuropilin-2; neuropilin-2a(17); neuropilin-2a(22); neuropilin-2b(0); receptor for VEGF165 and semaphorins class3; Vascular endothelial cell growth factor 165 receptor 2
基因别名: 1110048P06Rik; Np-2; NP2; Npn-2; NPN2; NRP2; PRO2714; VEGF165R2
UniProt ID: (Human) O60462, (Mouse) O35375, (Rat) O35276
Entrez Gene ID: (Human) 8828, (Mouse) 18187, (Rat) 81527
angiogenesis
positive regulation of endothelial cell proliferation
cell adhesion
axon guidance
positive regulation of endothelial cell migration
nerve development
vascular endothelial growth factor signaling pathway
vascular endothelial growth factor receptor signaling pathway
axon extension involved in axon guidance
sympathetic ganglion development
sympathetic neuron projection extension
sympathetic neuron projection guidance
semaphorin-plexin signaling pathway involved in neuron projection guidance
neural crest cell migration
neuron migration
multicellular organism development
nervous system development
heart development
facial nerve structural organization
vestibulocochlear nerve structural organization
gonadotrophin-releasing hormone neuronal migration to the hypothalamus
cell differentiation
ventral trunk neural crest cell migration
negative chemotaxis
trigeminal ganglion development
ganglion morphogenesis
semaphorin-plexin signaling pathway
sensory neuron axon guidance
neural crest cell migration involved in autonomic nervous system development
facioacoustic ganglion development
