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产品信息
PA5-65910
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2662162
产品详细信息
Immunogen sequence: PSGFNCNFDFL EEPCGWMYDH AKWLRTTWAS SSSPNDRTFP DDRNFLRLQS DSQREGQYAR LISPPVHLPR SPVCMEFQY
Highest antigen sequence identity to the following orthologs - mouse 85%, rat 83%.
靶标信息
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C) and SEMA3F protein (sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F), and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
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生物信息学
蛋白别名: Neuropilin-2; neuropilin-2a(17); neuropilin-2a(22); neuropilin-2b(0); receptor for VEGF165 and semaphorins class3; Vascular endothelial cell growth factor 165 receptor 2
基因别名: NP2; NPN2; NRP2; PRO2714; VEGF165R2
UniProt ID: (Human) O60462
Entrez Gene ID: (Human) 8828
angiogenesis
positive regulation of endothelial cell proliferation
cell adhesion
axon guidance
positive regulation of endothelial cell migration
nerve development
vascular endothelial growth factor signaling pathway
vascular endothelial growth factor receptor signaling pathway
axon extension involved in axon guidance
sympathetic ganglion development
sympathetic neuron projection extension
sympathetic neuron projection guidance
semaphorin-plexin signaling pathway involved in neuron projection guidance
