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Neutrophil elastase Antibody (MA5-42901) in IHC (P)
Immunohistochemistry analysis of Neutrophil elastase in paraffin-embedded mouse bone marrow. Samples were incubated with Neutrophil elastase Monoclonal antibody (Product # MA5-42901) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
产品信息
MA5-42901
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
8X4E6
抗原
A synthetic peptide corresponding to a sequence within amino acids 167-267 of human Neutrophil Elastase (ELANE) (P08246).
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2912042
产品详细信息
Positive test controls include: THP-1, U-937.
Immunogen sequence: SVLQELNVTV VTSLCRRSNV CTLVRGRQAG VCFGDSGSPL VCNGLIHGIA SFVRGGCASG LYPDAFAPVA QFVNWIDSII QRSEDNPCPH PRDPDPASRT H
靶标信息
The neutrophil form of elastase is 218 amino acids long, with two asparagine-linked carbohydrate chains (see glycosylation). It is present in azurophil granules in the neutrophil cytoplasm. There appear to be two forms of neutrophil elastase, termed IIa and IIb.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bone marrow serine protease; ELA2A; Elastase; elastase 2, neutrophil; Elastase-2; Elastase2; granulocyte-derived elastase; HLE; Human leukocyte elastase; Leukocyte elastase; Medullasin; Neutrophil elastase; PE-1; PMN elastase; polymorphonuclear elastase
基因别名: ELA2; ELANE; F430011M15Rik; GE; HLE; HNE; NE; PMN-E; SCN1
UniProt ID: (Human) P08246, (Mouse) Q3UP87
Entrez Gene ID: (Human) 1991, (Mouse) 50701
negative regulation of transcription from RNA polymerase II promoter
response to yeast
acute inflammatory response to antigenic stimulus
proteolysis
cellular calcium ion homeostasis
phagocytosis
response to UV
extracellular matrix disassembly
protein catabolic process
response to lipopolysaccharide
defense response to bacterium
positive regulation of MAP kinase activity
negative regulation of growth of symbiont in host
negative regulation of chemokine biosynthetic process
negative regulation of interleukin-8 biosynthetic process
positive regulation of interleukin-8 biosynthetic process
positive regulation of smooth muscle cell proliferation
negative regulation of inflammatory response
positive regulation of immune response
leukocyte migration
negative regulation of chemotaxis
neutrophil mediated killing of fungus
transcription from RNA polymerase II promoter
defense response to fungus
