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Alomone Labs, LTD
Nicotinic Acetylcholine Receptor alpha 3 (CHRNA3) (extracellular) Polyclonal Antibody
FIGURE: 1 / 2
Nicotinic Acetylcholine Receptor alpha 3 (CHRNA3) (extracellular) Antibody (ANC-003-200UL) in IHC (F)
Expression of Nicotinic acetylcholine receptor alpha 3 in rat neocortex - Immunohistochemical staining of immersion-fixed, free floating rat brain frozen sections were stained using Anti-Nicotinic Acetylcholine Receptor alpha 3 (CHRNA3) (extracellular) Antibody (#ANC-003), (1:200). A. Intense staining (green) of nAChR alpha 3 appears in apical dendrites (thin arrows). A few cortical interneurons (thick arro... View More
Product Details
ANC-003-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)KWKPSDYQGVEFMR, corresponding to amino acid residues 91-104 of rat nAChR alpha 3, Extracellular, N-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
CHRNA3 locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acetylcholine receptor; Acetylcholine receptor alpha 3 (neuronal nicotine); alpha 3; cetylcholine receptor alpha 3 (neuronal nicotine); cholinergic receptor; cholinergic receptor nicotinic alpha polypeptide 4; cholinergic receptor, nicotinic, alpha polypeptide 3; nAChR alpha 3; Neuronal acetylcholine receptor subunit alpha-3; neuronal nicotinic acetylcholine receptor, alpha 3 subunit
Gene Aliases: (a)3; A730007P14Rik; Acra-3; Acra3; Chrna3
UniProt ID: (Mouse) Q8R4G9
Entrez Gene ID: (Mouse) 110834, (Rat) 25101
transport
ion transport
cation transport
regulation of muscle contraction
regulation of smooth muscle contraction
signal transduction
activation of transmembrane receptor protein tyrosine kinase activity
chemical synaptic transmission
synaptic transmission, cholinergic
nervous system development
locomotory behavior
regulation of acetylcholine secretion, neurotransmission
behavioral response to nicotine
regulation of membrane potential
response to drug
regulation of dendrite morphogenesis
protein heterooligomerization
excitatory postsynaptic potential
synaptic transmission involved in micturition
cation transmembrane transport
heart development
response to inorganic substance
response to nicotine
Performance Guarantee
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