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Alomone Labs, LTD
Nicotinic Acetylcholine Receptor alpha 3 (CHRNA3) (extracellular) Polyclonal Antibody
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Nicotinic Acetylcholine Receptor alpha 3 (CHRNA3) (extracellular) Antibody (ANC-003-200UL) in IHC (F)
Expression of Nicotinic acetylcholine receptor alpha 3 in rat neocortex - Immunohistochemical staining of immersion-fixed, free floating rat brain frozen sections were stained using Anti-Nicotinic Acetylcholine Receptor alpha 3 (CHRNA3) (extracellular) Antibody (#ANC-003), (1:200). A. Intense staining (green) of nAChR alpha 3 appears in apical dendrites (thin arrows). A few cortical interneurons (thick arro... View More
产品信息
ANC-003-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)KWKPSDYQGVEFMR, corresponding to amino acid residues 91-104 of rat nAChR alpha 3, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
CHRNA3 locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acetylcholine receptor; Acetylcholine receptor alpha 3 (neuronal nicotine); alpha 3; cetylcholine receptor alpha 3 (neuronal nicotine); cholinergic receptor; cholinergic receptor nicotinic alpha polypeptide 4; cholinergic receptor, nicotinic, alpha polypeptide 3; nAChR alpha 3; Neuronal acetylcholine receptor subunit alpha-3; neuronal nicotinic acetylcholine receptor, alpha 3 subunit
基因别名: (a)3; A730007P14Rik; Acra-3; Acra3; Chrna3
UniProt ID: (Mouse) Q8R4G9
Entrez Gene ID: (Mouse) 110834, (Rat) 25101
transport
ion transport
cation transport
regulation of muscle contraction
regulation of smooth muscle contraction
signal transduction
activation of transmembrane receptor protein tyrosine kinase activity
chemical synaptic transmission
synaptic transmission, cholinergic
nervous system development
locomotory behavior
regulation of acetylcholine secretion, neurotransmission
behavioral response to nicotine
regulation of membrane potential
response to drug
regulation of dendrite morphogenesis
protein heterooligomerization
excitatory postsynaptic potential
synaptic transmission involved in micturition
cation transmembrane transport
heart development
response to inorganic substance
response to nicotine
