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产品信息
NACR-BIOTIN
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 25-75 on mouse GTPCHI protein.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Chromosome 15 encodes over 700 genes and comprises nearly 3% of the human genome. CHRFAM7A, a fusion protein comprised of FAM7A and AChR alpha7, is encoded by the CHRFAM7A gene, which is located on a region of human chromosome 15 that is associated with several neuropsychiatric disorders, such as schizophrenia and bipolar affective disorder. CHRFAM7A, also known as D-10 or CHRNA7, is a 412 amino acid multi-pass membrane protein that belongs to the nicotinic acetylcholine receptor (nAChR) subfamily of ligand-gated ion channel proteins, a protein superfamily that mediates signal transmission at synapses. CHRFAM7A is expressed in the hippocampus. Alternative splicing of the CHRFAM7A gene produces two splice variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acetylcholine receptor; acetylcholine receptor alpha 7 neural; alpha7 nicotinic receptor; alpha7-nAChR; bungarotoxin alpha; C holinergic receptor nicotinic alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha); C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha); cholinergic receptor; cholinergic receptor, nicotinic, alpha polypeptide 7; CHRFAM7A; CHRNA7-DR1; D-10; nAChR alpha7; Neuronal acetylcholine receptor subunit alpha-7; neuronal nicotinic acetycholine receptor alpha 7; nicotinic receptor alpha 7 subunit
基因别名: Acra7; alpha7; BTX; Chrna7; nAchR; nAChRa7; NARAD
UniProt ID: (Rat) Q05941, (Mouse) P49582
Entrez Gene ID: (Rat) 25302, (Mouse) 11441
beta-amyloid binding
acetylcholine-activated cation-selective channel activity
protein binding
drug binding
adenylate cyclase binding
acetylcholine receptor activity
toxic substance binding
chloride channel regulator activity
protein kinase binding
acetylcholine-gated cation channel activity
acetylcholine binding
protein homodimerization activity
ATPase binding
scaffold protein binding
ion channel activity
extracellular ligand-gated ion channel activity
ligand-gated ion channel
activation of MAPK activity
response to hypoxia
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure
ion transport
calcium ion transport
cellular calcium ion homeostasis
endocytosis
signal transduction
synaptic transmission, cholinergic
memory
positive regulation of cell proliferation
associative learning
regulation of norepinephrine secretion
neuronal action potential
sperm motility
response to food
regulation of synaptic transmission, dopaminergic
negative regulation of interleukin-1 beta production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
ion transmembrane transport
response to nicotine
behavioral response to nicotine
T cell activation
B cell activation
regulation of membrane potential
dopamine biosynthetic process
ovulation cycle
response to ethanol
positive regulation of angiogenesis
behavioral response to ethanol
regulation of inflammatory response
negative regulation of inflammatory response
cognition
generation of ovulation cycle rhythm
cation transmembrane transport
transport
