Alomone Labs, LTD

Nicotinic Acetylcholine Receptor beta 2 (CHRNB2) (extracellular) Polyclonal Antibody

View all (11) CHRNB2 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

ANC-012-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)EDFDNMKKVRLP, corresponding to amino acid residues 96-107 of rat nAChR beta 2, Extracellular, N-terminus
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: acetylcholine receptor; acetylcholine receptor beta 2 neural; acetylcholine receptor, nicotinic, beta 2 (neuronal); beta2 human neuronal nicotinic acetylcholine receptor; cholinergic receptor; cholinergic receptor nicotinic beta polypeptide 2; cholinergic receptor, nicotinic beta 2; cholinergic receptor, nicotinic, beta 2 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal); cholinergic receptor, nicotinic, beta subunit 2; N-alpha 1; Neuronal acetylcholine receptor non-alpha-1 chain; Neuronal acetylcholine receptor subunit beta-2; neuronal nicotinic acetylcholine receptor beta 2

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Gene Aliases: [b]2-nAchR; Acrb-2; Acrb2; C030030P04Rik; CHRNB2; EFNL3; nAChRB2

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UniProt ID: (Human) P17787, (Rat) P12390, (Mouse) Q8BGP7

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Entrez Gene ID: (Human) 1141, (Rat) 54239, (Mouse) 11444

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Function(s)
acetylcholine-activated cation-selective channel activity protein binding drug binding ligand-gated ion channel activity acetylcholine receptor activity acetylcholine binding protein heterodimerization activity ion channel activity extracellular ligand-gated ion channel activity ligand-gated ion channel
Process(es)
action potential conditioned taste aversion response to hypoxia ion transport calcium ion transport smooth muscle contraction signal transduction synaptic transmission, cholinergic neuromuscular synaptic transmission visual perception sensory perception of sound learning memory locomotory behavior associative learning visual learning regulation of dopamine secretion sensory perception of pain vestibulocochlear nerve development optic nerve morphogenesis lateral geniculate nucleus development central nervous system projection neuron axonogenesis positive regulation of B cell proliferation regulation of synaptic transmission, dopaminergic positive regulation of synaptic transmission, dopaminergic positive regulation of dopamine secretion response to nicotine behavioral response to nicotine social behavior regulation of dopamine metabolic process B cell activation response to cocaine regulation of circadian sleep/wake cycle, REM sleep regulation of circadian sleep/wake cycle, non-REM sleep response to ethanol negative regulation of action potential regulation of dendrite morphogenesis neurological system process cognition protein heterooligomerization membrane depolarization regulation of synapse assembly synaptic transmission involved in micturition cation transmembrane transport central nervous system neuron axonogenesis regulation of membrane potential transport
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