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产品信息
NKX2-C-BIOTIN
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
C-epitope synthetic peptide taken within amino acid region 200-273 on human homeobox protein Nkx-2.2
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Drosophila NK2 transcription factor related, locus 2; glycoprotein GP330, renal; Homeobox protein NK-2 homolog B; Homeobox protein Nkx-2.2; homeobox protein Nkx2-2; NK2 transcription factor related, locus 2; NK2 transcription factor-like protein B; Nkx2.2
基因别名: Nkx-2.2; NKX2-2; NKX2.2; NKX2B; tinman
UniProt ID: (Human) O95096, (Mouse) P42586
Entrez Gene ID: (Human) 4821, (Rat) 366214, (Mouse) 18088
core promoter proximal region DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
transcription factor binding
sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
molecular_function
DNA binding
protein binding
homeodomain transcription factor
type B pancreatic cell development
pancreatic A cell fate commitment
type B pancreatic cell fate commitment
pancreatic PP cell fate commitment
transcription, DNA-templated
smoothened signaling pathway
brain development
response to glucose
oligodendrocyte development
spinal cord motor neuron differentiation
spinal cord oligodendrocyte cell fate specification
optic nerve development
endocrine pancreas development
response to progesterone
negative regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
neuron fate specification
astrocyte differentiation
positive regulation of oligodendrocyte differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
ventral spinal cord interneuron fate determination
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
nervous system development
positive regulation of gene expression
response to organic cyclic compound
spinal cord oligodendrocyte cell differentiation
cell differentiation
regulation of cell differentiation
positive regulation of cell differentiation
cell development
multicellular organism development
