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Nkx3.1 Antibody (35-9700) in WB, ICC/IF
F1000Research 2016 -
Figure S1. Transfection of FLAG-NKX3.1 expression into LNCaP cells and affinity purification. ( A ) LNCaP cells were transfected with pFLAG-NKX3.1 plasmid or with the empty pFLAG vector. Total cell lysate (lanes 1 and 2) was absorbed to anti-FLAG resin and eluted with FLAG peptides (lanes 5 and 6). The depleted cell lysate after affinity purification is shown in lanes 3 and 4. Immunoblots were probed with t... View More
产品信息
35-9700
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
3 9
抗原
Fusion protein containing the N-terminal domain of the human Nkx3.1 protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.1% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2533232
靶标信息
The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Drosophila NK-3 transcription factor, locus 1; Homeobox protein NK-3 homolog A; Homeobox protein Nkx-3.1; NK homeobox, family 3, A; NK3 transcription factor homolog A; NK3 transcription factor related, locus 1; NKX3-1 antibody; prostate-specific ag
基因别名: bagpipe; BAPX2; Bax; Nkx-3.1; NKX3; NKX3-1; NKX3.1; NKX3A
UniProt ID: (Human) Q99801, (Mouse) P97436
Entrez Gene ID: (Human) 4824, (Mouse) 18095
transcription regulatory region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter sequence-specific
core promoter binding
transcription factor activity, sequence-specific DNA binding
androgen receptor activity
protein binding
transcription factor binding
cysteine-type endopeptidase activator activity involved in apoptotic process
estrogen receptor activity
protein kinase activator activity
estrogen receptor binding
histone deacetylase binding
sequence-specific DNA binding
protein self-association
transcription regulatory region DNA binding
MADS box domain binding
DNA binding
homeodomain transcription factor
metanephros development
somitogenesis
positive regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription, DNA-templated
activation of cysteine-type endopeptidase activity involved in apoptotic process
multicellular organism development
salivary gland development
heart development
positive regulation of cell proliferation
negative regulation of cell proliferation
male gonad development
positive regulation of gene expression
negative regulation of gene expression
positive regulation of cell death
positive regulation of phosphatidylinositol 3-kinase signaling
androgen receptor signaling pathway
activation of protein kinase activity
response to testosterone
cellular response to drug
dorsal aorta development
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein kinase B signaling
negative regulation of insulin-like growth factor receptor signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
negative regulation of mitotic cell cycle
positive regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
branching morphogenesis of an epithelial tube
negative regulation of epithelial cell proliferation
positive regulation of cell division
pharyngeal system development
branching involved in prostate gland morphogenesis
epithelial cell proliferation involved in salivary gland morphogenesis
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to steroid hormone stimulus
cellular response to hypoxia
mitotic cell cycle arrest
negative regulation of estrogen receptor binding
positive regulation of androgen secretion
positive regulation of response to DNA damage stimulus
positive regulation of apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway
urogenital system development
transcription from RNA polymerase II promoter
prostate gland development
internal genitalia morphogenesis
steroid hormone mediated signaling pathway
positive regulation of protein kinase activity
