Invitrogen

Noggin Polyclonal Antibody

查看其他19个Noggin抗体

产品信息

PA5-34595

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1 µg/mL

-

免疫组化（石蜡） (IHC (P))

1:175

-

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human Noggin.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.9 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2551947

产品详细信息

Not suitable for use with Immunohistochemistry - Free Floating.

This antibody is predicted to react with horse, chicken and Xenopus laevis based on sequence homology.

靶标信息

Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Noggin; Noggin precursor; symphalangism 1 (proximal)

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基因别名: NOG; SYM1; SYNS1; SYNS1A

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UniProt ID: (Human) Q13253, (Mouse) P97466

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Entrez Gene ID: (Human) 9241, (Mouse) 18121

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protein binding cytokine binding protein complex binding protein homodimerization activity intercellular signal molecule

negative regulation of transcription from RNA polymerase II promoter skeletal system development osteoblast differentiation in utero embryonic development endoderm formation mesoderm formation epithelial to mesenchymal transition neural plate morphogenesis neural tube closure nervous system development motor neuron axon guidance dorsal/ventral pattern formation spinal cord development cell differentiation in hindbrain pituitary gland development negative regulation of cell migration BMP signaling pathway negative regulation of BMP signaling pathway somatic stem cell population maintenance wound healing middle ear morphogenesis embryonic digit morphogenesis regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter axial mesoderm development notochord morphogenesis embryonic skeletal system development negative regulation of astrocyte differentiation positive regulation of epithelial cell proliferation cartilage development negative regulation of cardiac muscle cell proliferation limb development embryonic skeletal joint morphogenesis negative regulation of cytokine activity face morphogenesis negative regulation of pathway-restricted SMAD protein phosphorylation lung morphogenesis prostatic bud formation ureteric bud formation fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation negative regulation of cartilage development somite development negative regulation of canonical Wnt signaling pathway positive regulation of branching involved in ureteric bud morphogenesis positive regulation of glomerulus development regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation negative regulation of apoptotic signaling pathway urogenital system development ureteric bud development multicellular organism development pattern specification process axon guidance central nervous system development brain development negative regulation of gene expression neural tube development cell differentiation regulation of BMP signaling pathway negative regulation of cell differentiation anatomical structure formation involved in morphogenesis mesenchymal cell differentiation cellular response to BMP stimulus