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Npr2 Antibody (MA5-50136) in ICC/IF
Immunocytochemistry analysis of HeLa with Npr2 monoclonal antibody (Product # MA5-50136) at 1:25, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 501-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
产品信息
MA5-50136
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
19C7
抗原
A synthesized peptide derived from Human NPR2
偶联物
形式
Liquid
浓度
0.8 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_3092518
靶标信息
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide, which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ANP-B; ANPR-B; atrial natriuretic peptide B-type receptor; Atrial natriuretic peptide receptor 2; Atrial natriuretic peptide receptor type B; GC-B; guanylate cyclase 2B; Guanylate cyclase B; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B); NPR-B
基因别名: AMDM; ANPb; ANPRB; ECDM; GUC2B; GUCY2B; NPR2; NPRB; NPRBi; SNSK
UniProt ID: (Human) P20594
Entrez Gene ID: (Human) 4882
ossification
cGMP biosynthetic process
protein phosphorylation
receptor guanylyl cyclase signaling pathway
regulation of blood pressure
intracellular signal transduction
single organism reproductive process
negative regulation of meiotic cell cycle
bone development
cellular response to granulocyte macrophage colony-stimulating factor stimulus
negative regulation of oocyte maturation
regulation of cardiac conduction
