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Nrf2 Antibody (MA5-42371) in ICC/IF
Nrf2 Recombinant Rabbit Monoclonal Antibody (HL1021) detects NRF2 protein at nucleus by immunofluorescent analysis. Sample: Mock and treated HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: NRF2 stained by Nrf2 Recombinant Rabbit Monoclonal Antibody (HL1021) (Product # MA5-42371) diluted at 1:500. Blue: DAPI.
产品信息
MA5-42371
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1021
抗原
Recombinant protein encompassing a sequence within the center region of human NRF2. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2911512
产品详细信息
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
靶标信息
Nfr1 (also designated TCF11), Nrf2 and Nfr3 are bZIP transcription factors that heterodimer with Maf proteins to bind MARE (Maf recognition elements) sequences. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from a repressor protein Keap1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E4TF1-60; E4TF1A; NF-E2-related factor 2; NFE2-related factor 2; NFT2; nrf2; NRF2A; nuclear factor erythroid 2-like 2; Nuclear factor erythroid 2-related factor 2; nuclear factor erythroid-derived 2-like 2; nuclear factor, erythroid 2-like 2; Nuclear factor, erythroid derived 2, like 2
基因别名: AI194320; HEBP1; NFE2L2; NRF2
UniProt ID: (Human) Q16236, (Mouse) Q60795, (Rat) O54968
Entrez Gene ID: (Human) 4780, (Mouse) 18024, (Rat) 83619
transcription regulatory region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II activating transcription factor binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcription cofactor binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein domain specific binding
transcription regulatory region DNA binding
sequence-specific DNA binding
protein heterodimerization activity
basic leucine zipper transcription factor
transcription from RNA polymerase II promoter
inflammatory response
proteasomal ubiquitin-independent protein catabolic process
positive regulation of gene expression
protein ubiquitination
positive regulation of blood coagulation
endoplasmic reticulum unfolded protein response
cellular response to oxidative stress
cellular response to drug
positive regulation of transcription from RNA polymerase II promoter in response to stress
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
PERK-mediated unfolded protein response
cellular response to glucose starvation
proteasome-mediated ubiquitin-dependent protein catabolic process
cell redox homeostasis
positive regulation of transcription from RNA polymerase II promoter
regulation of embryonic development
positive regulation of glucose import
cellular response to hydrogen peroxide
cellular response to tumor necrosis factor
cellular response to fluid shear stress
cellular response to laminar fluid shear stress
negative regulation of hematopoietic stem cell differentiation
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
negative regulation of hydrogen peroxide-induced cell death
positive regulation of glutathione biosynthetic process
regulation of removal of superoxide radicals
negative regulation of endothelial cell apoptotic process
positive regulation of reactive oxygen species metabolic process
transcription, DNA-templated
regulation of transcription, DNA-templated
response to endoplasmic reticulum stress
positive regulation of transcription, DNA-templated
negative regulation of cell death
