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Nucleobindin-2/Nesfatin-1 Antibody (ACS-011-200UL) in IHC (F)
Expression of Nucleobindin-2/Nesfatin-1 in rat hypothalamus. Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Anti-Nucleobindin-2/Nesfatin-1 Antibody (#ACS-011), (1:1200), followed by goat Anti-rabbit-Alexa-488. A. Staining in the ventromedial hypothalamus (VMH) region showed Nucleobindin-2/Nesfatin-1 immunoreactivity (green) in VMH neurons (arrows). B. Pre-incubation of the An... View More
产品信息
ACS-011-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)DKTKVHNVEPVESAR, corresponding to amino acid residues 30-44 of rat Nucleobindin-2/Nesfatin-1, Intracellular
偶联物
形式
Lyophilized
浓度
0.85 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
NUCB2 was initially identified as calcium-binding protein EF hand motif-containing protein that could bind with Necdin, a growth suppressor expressed primarily in postmitotic neurons. NUC2 is a secreted protein that is cleaved into three major peptide products, Nesfatin-1, Nesfatin-2, and Nesfatin-3, of which Nesfatin-1 has been found to cause the suppression of food intake in a leptin-independent manner. Other studies have suggested that NUCB2/Nesfatin-1 may also play roles in energy homeostasis and closely related neuroendocrine functions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNA-binding protein NEFA; Epididymis secretory protein Li 109; Gastric cancer antigen Zg4; nesfatin 1; nesfatin-1; Nucleobindin-2; Nucleobindin-2/Nesfatin-1; nucleobinding 2; prepronefastin; Prepronesfatin
基因别名: AI607786; Calnuc; HEL-S-109; NEFA; Nesfatin-1; NUCB2; p54
UniProt ID: (Human) P80303, (Mouse) P81117, (Rat) Q9JI85
Entrez Gene ID: (Human) 4925, (Mouse) 53322, (Rat) 59295
cellular calcium ion homeostasis
negative regulation of cAMP biosynthetic process
negative regulation of appetite
negative regulation of fat cell differentiation
positive regulation of fatty acid oxidation
negative regulation of insulin receptor signaling pathway
negative regulation of glucagon secretion
insulin metabolic process
positive regulation of testosterone secretion
