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Nudel Antibody (PA5-96422) in WB
Western blot analysis of Nudel in extracts of various cell lines. Samples were incubated with Nudel Polyclonal antibody (Product # PA5-96422) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-96422
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-345 of human NUDEL/NUDEL/NDEL1 (NP_1104351)
偶联物
形式
Liquid
浓度
0.73 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808224
产品详细信息
Immunogen sequence: MDGEDIPDFS SLKEETAYWK ELSLKYKQSF QEARDELVEF QEGSRELEAE LEAQLVQAEQ RNRDLQADNQ RLKYEVEALK EKLEHQYAQS YKQVSVLEDD LSQTRAIKEQ LHKYVRELEQ ANDDLERAKR ATIVSLEDFE QRLNQAIERN AFLESELDEK ESLLVSVQRL KDEARDLRQE LAVRERQQEV TRKSAPSSPT LDCEKMDSAV QASLSLPATP VGKGTENTFP SPKAIPNGFG TSPLTPSARI SALNIVGDLL RKVGALESKL AACRNFAKDQ ASRKSYISGN VNCGVLNGNG TKFSRSGHTS FFDKGAVNGF DPAPPPPGLG SSRPSSAPGM LPLSV; Positive Samples: U-87MG, Mouse brain; Cellular Location: Chromosome, Cytoplasm, centromere, centrosome, cytoskeleton, kinetochore, microtubule organizing center, spindle
靶标信息
This gene encodes a thiol-activated peptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp451M0318; endooligopeptidase A; Mitosin-associated protein 1; mitosin-associated protein MITAP1; mNudE-L; nuclear disribution gene E like; Nuclear distribution protein nudE-like 1; nudE neurodevelopment protein 1-like 1; nudE nuclear distribution E homolog-like 1; nudE nuclear distribution gene E homolog-like 1; NUDE-like protein; Protein mNudE-like; Protein Nudel
基因别名: 2600006O07Rik; EOPA; MITAP1; mNudel; NDE1L1; NDE2; NDEL1; NUDEL
UniProt ID: (Human) Q9GZM8, (Mouse) Q9ERR1
Entrez Gene ID: (Human) 81565, (Mouse) 83431
establishment of mitotic spindle orientation
neuron migration
inner cell mass cell proliferation
proteolysis
microtubule nucleation
chromosome segregation
sister chromatid cohesion
mitotic centrosome separation
retrograde axonal transport
regulation of neuron projection development
cell migration
cerebral cortex radially oriented cell migration
central nervous system neuron axonogenesis
regulation of intracellular protein transport
positive regulation of GTPase activity
positive regulation of axon extension
vesicle transport along microtubule
positive regulation of axon regeneration
nuclear envelope disassembly
establishment of chromosome localization
centrosome localization
neurofilament cytoskeleton organization
activation of GTPase activity
neuron projection extension
regulation of microtubule motor activity
microtubule cytoskeleton organization
transport
multicellular organism development
nervous system development
cell differentiation
neuron projection development
canonical Wnt signaling pathway
