Invitrogen

OAS1 Polyclonal Antibody

OAS1 Antibody in Immunocytochemistry (ICC/IF)

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OAS1 Antibody (PA5-82113) in ICC/IF

Immunofluorecent analysis of OAS1 in human cell line A-431 using OAS1 Polyclonal Antibody (Product # PA5-82113). Staining shows localization to cytosol.

OAS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

PA5-82113

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500

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免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human OAS1. Recombinant protein control fragment (Product #RP-102253).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2789274

产品详细信息

Immunogen sequence: VFLSPLTTFQ DQLNRRGEFI QEIRRQLEAC QRERAFSVKF EVQAPRWGNP RALSFVLSSL QLGEGVEFDV LPAFDALGQL TGGYKPNPQI YVKLIEECTD LQKEGEFSTC FTELQRDFLK QRPTKLKSLI RLVKHWYQNC KK

靶标信息

OAS1 is an interferon inducible protein that may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. It binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. This protein is associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries.

Nature genetics

Banday AR,Stanifer ML,Florez-Vargas O,Onabajo OO,Papenberg BW,Zahoor MA,Mirabello L,Ring TJ,Lee CH,Albert PS,Andreakos E,Arons E,Barsh G,Biesecker LG,Boyle DL,Brahier MS,Burnett-Hartman A,Carrington M,Chang E,Choe PG,Chisholm RL,Colli LM,Dalgard CL,Dude CM,Edberg J,Erdmann N,Feigelson HS,Fonseca BA,Firestein GS,Gehring AJ,Guo C,Ho M,Holland S,Hutchinson AA,Im H,Irby L,Ison MG,Joseph NT,Kim HB,Kreitman RJ,Korf BR,Lipkin SM,Mahgoub SM,Mohammed I,Paschoalini GL,Pacheco JA,Peluso MJ,Rader DJ,Redden DT,Ritchie MD,Rosenblum B,Ross ME,Anna HPS,Savage SA,Sharma S,Siouti E,Smith AK,Triantafyllia V,Vargas JM,Vargas JD,Verma A,Vij V,Wesemann DR,Yeager M,Yu X,Zhang Y,Boulant S,Chanock SJ,Feld JJ,Prokunina-Olsson L

PA5-82113 was used in Immunocytochemistry-immunoflourescence to report genetic, functional and clinical insights into this locus in relation to COVID-19 severity.

Mon Aug 01 00:00:00 UTC 2022

Genetic regulation of OAS1 nonsense-mediated decay underlies association with risk of severe COVID-19.

medRxiv : the preprint server for health sciences

Banday AR,Stanifer ML,Florez-Vargas O,Onabajo OO,Zahoor MA,Papenberg BW,Ring TJ,Lee CH,Andreakos E,Arons E,Barsh G,Biesecker LG,Boyle DL,Burnett-Hartman A,Carrington M,Chang E,Choe PG,Chrisholm RL,Dalgard C,Edberg J,Erdmann N,Feigelson HS,Firestein GS,Gehring AJ,Ho M,Holland S,Hutchinson AA,Im H,Ison MG,Kim HB,Kreitman RJ,Korf BR,Mirabello L,Pacheco JA,Peluso MJ,Rader DJ,Redden DT,Ritchie MD,Rosenbloom B,Sant Anna HP,Savage S,Siouti E,Triantafyllia V,Vargas JM,Verma A,Vij V,Wesemann DR,Yeager M,Yu X,Zhang Y,Boulant S,Chanock SJ,Feld JJ,Prokunina-Olsson L

Published figure using OAS1 polyclonal antibody (Product # PA5-82113) in Western Blot

Tue Jul 13 00:00:00 UTC 2021

Genetic regulation of OAS1 nonsense-mediated decay underlies association with risk of severe COVID-19.

medRxiv : the preprint server for health sciences

Published figure using OAS1 polyclonal antibody (Product # PA5-82113) in Western Blot

Tue Jul 13 00:00:00 UTC 2021

生物信息学

蛋白别名: (2-5')oligo(A) synthase 1; 2',5'-oligo A synthetase 1; 2'-5'-oligoadenylate synthase 1; 2'-5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5'-oligoisoadenylate synthetase 1; 2-5A synthase 1; 2-5A synthetase 1; E16 (2'-5') oligo A synthetase; E18/E16; IFI 4; IFI4; OAS 1; p46/p42 OAS

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基因别名: E18/E16; IFI-4; OAS1; OIAS; OIASI

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UniProt ID: (Human) P00973

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Entrez Gene ID: (Human) 4938

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功能

2'-5'-oligoadenylate synthetase activity double-stranded RNA binding protein binding ATP binding metal ion binding nucleotidyltransferase

参与通路

glucose metabolic process response to virus glucose homeostasis negative regulation of viral genome replication defense response to virus interferon-gamma-mediated signaling pathway type I interferon signaling pathway