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产品信息
PA5-75631
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues in Human OAZ3.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2719359
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
The antizyme family is a group of small proteins that play a role in cell growth and division by regulating the biosynthesis of polyamines such as putrescine, spermidine and spermine. AZ3, also known as OAZ3 (Ornithine decarboxylase antizyme 3), is a 187 amino acid protein that belongs to the ODC antizyme family. AZ3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells because it binds to, and destabilizes, ornithine decarboxylase. However, mutations in the AZ3 gene are not a common cause of male infertility and the normal AZ3 protein does not accelerate ornithine decarboxylase degeneration. AZ3 expression has a sharp onset in early spermatids, peaks in later stages and is gone in spermatozoa.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: antizyme 3; AZ3; OAZ-t; ODC-Az 3; Ornithine decarboxylase antizyme 3; testicular secretory protein Li 31; testis specific ornithine decarboxylase antizyme
基因别名: Az-3; AZ3; OAZ-t; OAZ3; ODC-Az 3; TISP15
UniProt ID: (Human) Q9UMX2, (Mouse) Q9R109, (Rat) A1BPI0
Entrez Gene ID: (Human) 51686, (Mouse) 53814, (Rat) 689588
regulation of cellular amino acid metabolic process
polyamine biosynthetic process
spermatogenesis
putrescine transport
negative regulation of catalytic activity
positive regulation of protein catabolic process
negative regulation of polyamine transmembrane transport
polyamine metabolic process
regulation of phosphoprotein phosphatase activity
ammonium transmembrane transport
positive regulation of intracellular protein transport
polyamine transmembrane transport
cation transmembrane transport
