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产品信息
PA5-70578
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide directed towards the middle region of human OBFC1 (aa 297-346)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2689685
产品详细信息
This target displays homology in the following species: Cow: 79%; Dog: 86%; Guinea Pig: 79%; Horse: 93%; Human: 100%; Mouse: 86%; Pig: 86%; Rat: 79%
靶标信息
OBFC1 is a component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha accessory factor 44; CST complex subunit STN1; oligonucleotide/oligosaccharide-binding fold containing 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 1; replication protein A 32 kDa subunit; Suppressor of cdc thirteen homolog
基因别名: AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32; STN1
UniProt ID: (Human) Q9H668
Entrez Gene ID: (Human) 79991
telomere maintenance
telomere maintenance via telomere lengthening
telomere capping
positive regulation of telomere maintenance via telomerase
positive regulation of DNA replication
positive regulation of telomerase activity
negative regulation of telomerase activity
regulation of telomere maintenance via telomere lengthening
