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产品信息
PA5-98026
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human N-glycosylase/DNA lyase protein (1-345AA)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2812640
靶标信息
8-hydroxyguanine, a form of oxidative DNA damage induced by free radicals, causes G:C to T:A transversion. In E. Coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine. One of these enzymes, MutM, was found to have a functional yeast (yOgg1) and human (hOgg1) homologue. hOgg1 proteins efficiently released the 8-hydroxyguanine opposite the pyrimidine from DNA and cleaved the AP site in a manner similar to bacterial and yeast enzymes. Genetic backgrounds in control of the repair of damaged DNA are involved in the susceptibility to cancer development. The hOgg1 gene has been mapped to region 3p26. 2, a region showing loss of heterozygosity (LOH) in a variety of cancers. In particular, 3p25-p26 is a common LOH region in lung cancer.
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生物信息学
蛋白别名: 8-hydroxyguanine DNA glycosylase; AP lyase; DNA-apurinic or apyrimidinic site lyase; N-glycosylase/DNA lyase; OGG1 type 1f
基因别名: HMMH; HOGG1; MMH; MUTM; OGG1; OGH1
UniProt ID: (Human) O15527
Entrez Gene ID: (Human) 4968
acute inflammatory response
base-excision repair
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
response to oxidative stress
aging
response to radiation
response to light stimulus
response to estradiol
regulation of protein import into nucleus, translocation
nucleotide-excision repair, DNA incision
response to drug
negative regulation of apoptotic process
depurination
depyrimidination
response to ethanol
response to folic acid
cellular response to cadmium ion
negative regulation of double-strand break repair via single-strand annealing
