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产品信息
MA5-23805
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
257224
抗原
E. coli-derived recombinant human Olig1 (aa 1-272)
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2607923
产品详细信息
In direct ELISAs, this antibody shows approximately 20% cross-reactivity with recombinant human (rh) Olig2 and 50-100% cross-reactivity with rhOlig3.
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
Olig1 promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube. Olig2 is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: basic domain, helix-loop-helix protein, class B, 1; basic domain, helix-loop-helix protein, class B, 6; bHLHb1; bHLHb6; bHLHb7; bHLHe19; bHLHe20; bHLHe21; Class B basic helix-loop-helix protein 1; Class B basic helix-loop-helix protein 6; Class B basic helix-loop-helix protein 7; Class E basic helix-loop-helix protein 19; Class E basic helix-loop-helix protein 20; Class E basic helix-loop-helix protein 21; human protein kinase C-binding protein RACK17; olig-2; Oligo1; Oligo2; Oligo2 antibody; Oligo3; oligodendrocyte lineage transcription factor 1; Oligodendrocyte transcription factor 1; Oligodendrocyte transcription factor 2; Oligodendrocyte transcription factor 3; oligodendrocyte-specific bHLH transcription factor 1; oligodendrocyte-specific bHLH transcription factor 2; Protein kinase C-binding protein 2; Protein kinase C-binding protein RACK17
基因别名: BHLHB1; BHLHB6; BHLHB7; BHLHE19; BHLHE20; BHLHE21; OLIG1; OLIG2; OLIG3; OLIGO2; PRKCBP2; RACK17
UniProt ID: (Human) Q8TAK6, (Human) Q13516, (Human) Q7RTU3
Entrez Gene ID: (Human) 116448, (Human) 10215, (Human) 167826
DNA binding
protein binding
protein dimerization activity
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein homodimerization activity
HMG box domain binding
RNA polymerase II transcription corepressor activity
basic helix-loop-helix transcription factor
transcription, DNA-templated
regulation of transcription, DNA-templated
neuron fate commitment
oligodendrocyte differentiation
negative regulation of transcription from RNA polymerase II promoter
spinal cord motor neuron differentiation
spinal cord oligodendrocyte cell fate specification
thalamus development
myelination
negative regulation of neuron differentiation
positive regulation of oligodendrocyte differentiation
spinal cord motor neuron cell fate specification
spinal cord motor neuron migration
