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Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Oligophrenin-1
基因别名: C130037N19Rik; Ophn1
UniProt ID: (Mouse) Q99J31
Entrez Gene ID: (Mouse) 94190