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OSGEPL1 Antibody (PA5-117114) in IHC (P)
Immunohistochemistry analysis of OSGEPL1 in paraffin-embedded human liver damage. Samples were incubated with OSGEPL1 Polyclonal antibody (Product # PA5-117114) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-117114
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human OSGEPL1 (NP_0717482)
Conjugate
Form
Liquid
Concentration
0.88 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2901744
Product Specific Information
Positive Samples: Mouse heart, Mouse kidney, Mouse liver, Mouse testis, Rat liver, Rat brain
Immunogen sequence: MLILTKTAGV FFKPSKRKVY EFLRSFNFHP GTLFLHKIVL GIETSCDDTA AAVVDETGNV LGEAIHSQTE VHLKTGGIVP PAAQQLHREN IQRIVQEALS ASGVSPSDLS AIATTIKPGL ALSLGVGLSF SLQLVGQLKK PFIPIHHMEA HALTIRLTNK VEFPFLVLLI SGGHCLLALV QGVSDFLLLG KSLDIAPGDM LDKVARRLSL IKHPECSTMS GGKAIEHLAK QGNRFHFDIK PPLHHAKNCD FSFTGLQHVT DKIIMKKEKE
Target Information
OSGEPL1, also known as Qri7, is a 414 amino acid protein that belongs to the KAE1/YgjD family and exists as 3 alternatively spliced isoforms. In tRNAs that have codons beginning with adenine, OSGEPL1 is required for the formation of a threonylcarbamoyl group on adenosine. The gene that encodes OSGEPL1 contains about 16,568 bases and maps to human chromosome 2q32.2. Consisting of 237 million bases, chromosome 2 encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstrom syndrome, is due to mutations in the ALMS1 gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: N6-L-threonylcarbamoyladenine synthase; O-sialoglycoprotein endopeptidase like 1; O-sialoglycoprotein endopeptidase-like protein 1; O-sialoglycoprotein endopeptidase-like protein 1 {ECO:0000255|HAMAP-Rule:MF_03179}; OSGEP-like protein 1; OSGEPL1; probable O-sialoglycoprotein endopeptidase 2; probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03179}; probable tRNA threonylcarbamoyladenosine biosynthesis protein OSGEPL1; putative sialoglycoprotease type 2; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEPL1; t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1 {ECO:0000255|HAMAP-Rule:MF_03179}; tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; tRNA threonylcarbamoyladenosine biosynthesis protein OSGEPL1; tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1 {ECO:0000255|HAMAP-Rule:MF_03179}
Gene Aliases: 2610001M19Rik; AA416452; GCP1; OSGEPL1; Qri7
UniProt ID: (Human) Q9H4B0, (Mouse) Q6PEB4
Entrez Gene ID: (Human) 64172, (Mouse) 72085, (Rat) 314548
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