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OX40L (CD252) Antibody (PA5-80169) in IHC (P)
Immunohistochemistry analysis of OX40L (CD252) on paraffin-embedded rat small intestine tissue. Antigen retrieval was performed using citrate buffer (pH6, epitope retrieval solution) for 20 mins. Sample was blocked using 10% goat serum, incubated with OX40L (CD252) polyclonal antibody (Product# PA5-80169) with a dilution of 1 µg/mL (overnight at 4°C), and followed by biotinylated goat anti-rabbit IgG (30 mi... View More
产品信息
PA5-80169
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived mouse CD252 recombinant protein (Position: Q49-L198).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2747283
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
The tumor necrosis factor superfamily member TNFSF4 is a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells, such as dendritic cells and activated B-cells, and also on other cells such as vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNgamma. TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: atherosclerosis 1; CD252; OX40 ligand; OX40L; tax-transcriptionally activated glycoprotein 1 ligand; Tumor necrosis factor ligand superfamily member 4
基因别名: Ath-1; Ath1; CD134L; gp34; OX-40L; Ox40l; Tnfsf4; TXGP1; Txgp1l
UniProt ID: (Rat) Q9Z2P3, (Mouse) P43488
Entrez Gene ID: (Rat) 89814, (Mouse) 22164
cytokine production
defense response to nematode
acute inflammatory response
positive regulation of T cell cytokine production
regulation of adaptive immune response
positive regulation of type 2 immune response
positive regulation of immunoglobulin mediated immune response
inflammatory response
immune response
cholesterol metabolic process
response to virus
negative regulation of interferon-gamma production
negative regulation of interleukin-17 production
positive regulation of interferon-gamma production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-13 production
positive regulation of interleukin-2 production
positive regulation of interleukin-4 production
positive regulation of interleukin-6 production
memory T cell activation
T-helper 2 cell activation
response to nitrogen dioxide
cellular response to nitrogen dioxide
CD4-positive, alpha-beta T cell costimulation
T cell proliferation
positive regulation of activated T cell proliferation
positive regulation of CD4-positive, alpha-beta T cell differentiation
positive regulation of memory T cell differentiation
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of regulatory T cell differentiation
negative regulation of T-helper 1 cell differentiation
positive regulation of T-helper 2 cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of alpha-beta T cell proliferation
negative regulation of cytokine secretion
regulation of inflammatory response
positive regulation of inflammatory response
positive regulation of B cell activation
positive regulation of immunoglobulin secretion
cellular response to lipopolysaccharide
cellular response to prostaglandin E stimulus
chemokine (C-C motif) ligand 11 production
positive regulation of CD4-positive, alpha-beta T cell costimulation
positive regulation of T cell costimulation
positive regulation of memory T cell activation
positive regulation of T-helper 2 cell activation
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes
blood vessel development
positive regulation of immune effector process
innate immune response
negative regulation of T cell apoptotic process
negative regulation of activation-induced cell death of T cells
positive regulation of T cell migration
negative regulation of extrinsic apoptotic signaling pathway
