Osenses

Optineurin Polyclonal Antibody

Optineurin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Optineurin Antibody (OSO00040W-100UL) in IHC (P)

IHC-P on paraffin sections of mouse testis. The animal was perfused using Autoperfuser at a pressure of 130 mmHg with 300 mL 4% FA and further post fixed overnight before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instruction... View More

Optineurin Antibody in Western Blot (WB)

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产品信息

OSO00040W-100UL

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:2,000

免疫组化（石蜡） (IHC (P))

1:1,000

其他PubMed (Misc)

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产品规格

种属反应

Mouse

已发表种属

Not Applicable

宿主/亚型

Rabbit / Ig

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide from internal region of mouse Optineurin conjugated to blue carrier protein was used as the antigen

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

Conc. Not Determined

保存液

whole serum

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Specificity of this antibody: Optineurin.

靶标信息

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14. 7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

仅用于科研。不用于诊断过程。未经明确授权不得转售。