Invitrogen

Osteocalcin Polyclonal Antibody

Osteocalcin Antibody in Immunocytochemistry (ICC/IF)

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Osteocalcin Antibody (PA5-96529) in ICC/IF

Immunofluorescence analysis of Osteocalcin in NIH/3T3 cells. Samples were incubated with Osteocalcin Polyclonal antibody (Product # PA5-96529) using a dilution of 1:200 (40x lens). Blue: DAPI for nuclear staining.

Osteocalcin Antibody in Western Blot (WB)

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产品信息

PA5-96529

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫组化 (IHC)

- -

免疫组化（石蜡） (IHC (P))

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免疫细胞化学 (ICC/IF)

1:50-1:200

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酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Osteocalcin (BGLAP) (NP_9546421)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.62 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2808331

产品详细信息

Immunogen sequence: MRALTLLALL ALAALCIAGQ AGAKPSGAES SKGAAFVSKQ EGSEVVKRPR RYLYQWLGAP VPYPDPLEPR REVCELNPDC DELADHIGFQ EAYRRFYGPV

靶标信息

Osteocalcin belongs to the osteocalcin/matrix Gla-protein family and constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

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PA5-96529 was used in Immunocytochemistry to show that the magnetic magnesium-loaded scaffold, under the action of SMF, can accelerate the inflow of Mg2+ from surrounding microenvironment, which improved cellular activities, osteogenesis-related gene expression (ALP, Runx2, OCN, and OPN), and mineralization.

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3D-printed NIR-responsive shape memory polyurethane/magnesium scaffolds with tight-contact for robust bone regeneration.

Bioactive materials

Zhang Y,Li C,Zhang W,Deng J,Nie Y,Du X,Qin L,Lai Y

PA5-96529 was used in Immunohistochemistry (Paraffin) to report a near-infrared-responsive and tight-contacting scaffold that comprises of shape memory polyurethane (SMPU) as the thermal-responsive matrix and magnesium (Mg) as the photothermal and bioactive component, which fabricated by the low temperature rapid prototyping (LT-RP) 3D printing technology.

Sat Oct 01 00:00:00 UTC 2022

Mechanics-driven nuclear localization of YAP can be reversed by N-cadherin ligation in mesenchymal stem cells.

Nature communications

Zhang C,Zhu H,Ren X,Gao B,Cheng B,Liu S,Sha B,Li Z,Zhang Z,Lv Y,Wang H,Guo H,Lu TJ,Xu F,Genin GM,Lin M

PA5-96529 was used in Immunocytochemistry to demonstrate that controlled storage and removal of proteins associated with mechanical memory in mesenchymal stem cells is possible through defined and programmable material systems.

Thu Oct 28 00:00:00 UTC 2021

Mechanics-driven nuclear localization of YAP can be reversed by N-cadherin ligation in mesenchymal stem cells.

Nature communications

Zhang C,Zhu H,Ren X,Gao B,Cheng B,Liu S,Sha B,Li Z,Zhang Z,Lv Y,Wang H,Guo H,Lu TJ,Xu F,Genin GM,Lin M

Thu Oct 28 00:00:00 UTC 2021

生物信息学

蛋白别名: BGP; bone gamma carboxyglutamate protein 1; bone gamma-carboxyglutamate (gla) protein (osteocalcin); bone gamma-carboxyglutamate protein 2; bone gamma-carboxyglutamic acid (Gla) protein (osteocalcin); Bone Gla protein; bone Gla-protein; Gamma-carboxyglutamic acid-containing protein; OG1; Osteocalcin; PMF1; RP11-54H19.5

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基因别名: BGLAP; Bglap1; Bglap2; BGP; Bgpr; Bgpra; mOC-A; OC; OCN; OG1

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UniProt ID: (Human) P02818, (Mouse) P86546, (Rat) P04640

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Entrez Gene ID: (Human) 632, (Mouse) 12096, (Rat) 25295

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功能

structural molecule activity calcium ion binding structural constituent of bone hydroxyapatite binding metal ion binding

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