Product References
Remdesivir increases mtDNA copy number causing mild alterations to oxidative phosphorylation.
Scientific reports
DeFoor N,Paul S,Li S,Basso EKG,Stevenson V,Browning JL,Prater AK,Brindley S,Tao G,Pickrell AM
45-8199 was used in Western Blot to show that certain nucleoside analogues unintentionally inhibit mitochondrial RNA or DNA polymerases or cause mutational changes to mitochondrial DNA (mtDNA).
Fri Sep 15 00:00:00 UTC 2023
Mitochondrial modulation with leriglitazone as a potential treatment for Rett syndrome.
Journal of translational medicine
Musokhranova U,Grau C,Vergara C,Rodríguez-Pascau L,Xiol C,Castells AA,Alcántara S,Rodríguez-Pombo P,Pizcueta P,Martinell M,García-Cazorla A,Oyarzábal A
45-8199 was used in Western Blot to describe mitochondrial alterations in Rett fibroblasts regarding both shape and bioenergetic functions, as they displayed less interconnected and shorter mitochondria and reduced ATP production along with increased oxidative stress.
Thu Oct 26 00:00:00 UTC 2023
Leigh syndrome is the main clinical characteristic of PTCD3 deficiency.
Brain pathology (Zurich, Switzerland)
Muñoz-Pujol G,Ortigoza-Escobar JD,Paredes-Fuentes AJ,Jou C,Ugarteburu O,Gort L,Yubero D,García-Cazorla A,O'Callaghan M,Campistol J,Muchart J,Yépez VA,Gusic M,Gagneur J,Prokisch H,Artuch R,Ribes A,Urreizti R,Tort F
45-8199 was used in Western Blot to provide evidence of PTCD3 involvement in human disease confirming that PTCD3 deficiency is definitively associated with Leigh syndrome.
Mon May 01 00:00:00 UTC 2023
Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability.
Nature communications
Erdem A,Marin S,Pereira-Martins DA,Geugien M,Cunningham A,Pruis MG,Weinhäuser I,Gerding A,Bakker BM,Wierenga ATJ,Rego EM,Huls G,Cascante M,Schuringa JJ
Published figure using OxPhos Human WB cocktail antibody (Product # 45-8199) in Western Blot
Tue Apr 19 00:00:00 UTC 2022
The Combination of Δ9-Tetrahydrocannabinol and Cannabidiol Suppresses Mitochondrial Respiration of Human Glioblastoma Cells via Downregulation of Specific Respiratory Chain Proteins.
Cancers
Rupprecht A,Theisen U,Wendt F,Frank M,Hinz B
45-8199 was used in Western Blotting to describe a previously unknown mitochondria-targeting mechanism behind the toxic effect of THC and CBD on glioblastoma cells that should be considered in future cancer therapy, especially in combination strategies with other chemotherapeutics.
Mon Jun 27 00:00:00 UTC 2022
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development.
Cell stem cell
Johansson PA,Brattås PL,Douse CH,Hsieh P,Adami A,Pontis J,Grassi D,Garza R,Sozzi E,Cataldo R,Jönsson ME,Atacho DAM,Pircs K,Eren F,Sharma Y,Johansson J,Fiorenzano A,Parmar M,Fex M,Trono D,Eichler EE,Jakobsson J
45-8199 was used in Western Blotting to provide mechanistic insight into how a cis-acting structural variation establishes a regulatory network that affects human brain evolution.
Thu Jan 06 00:00:00 UTC 2022
The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia.
Nature communications
Erdem A,Marin S,Pereira-Martins DA,Cortés R,Cunningham A,Pruis MG,de Boer B,van den Heuvel FAJ,Geugien M,Wierenga ATJ,Brouwers-Vos AZ,Rego EM,Huls G,Cascante M,Schuringa JJ
45-8199 was used in Western Blot to show that human leukemias display distinct metabolic states and adaptation mechanisms that can serve as targets for treatment.
Tue Mar 01 00:00:00 UTC 2022
Reconstruction of functional human epidermis equivalent containing 5%IPS-derived keratinocytes treated with mitochondrial stimulating plant extracts.
Scientific reports
Moreau M,Capallere C,Chavatte L,Plaza C,Meyrignac C,Pays K,Bavouzet B,Botto JM,Nizard C,Bulteau AL
45-8199 was used in Western Blotting to suggest that improving mitochondrial function in KiPS is one of the key aspects to obtain a functional RHE and that our plant extracts can improve in this process.
Tue May 31 00:00:00 UTC 2022
Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation.
Nature communications
Chung CY,Singh K,Kotiadis VN,Valdebenito GE,Ahn JH,Topley E,Tan J,Andrews WD,Bilanges B,Pitceathly RDS,Szabadkai G,Yuneva M,Duchen MR
45-8199 was used in Western Blotting to reveal that the mutation promotes changes in metabolites which are associated with the upregulation of the PI3K-Akt-mTORC1 axis in patient-derived cells and tissues.
Thu Nov 04 00:00:00 UTC 2021
Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation.
Nature communications
Chung CY,Singh K,Kotiadis VN,Valdebenito GE,Ahn JH,Topley E,Tan J,Andrews WD,Bilanges B,Pitceathly RDS,Szabadkai G,Yuneva M,Duchen MR
45-8199 was used in Western Blotting to reveal that the mutation promotes changes in metabolites which are associated with the upregulation of the PI3K-Akt-mTORC1 axis in patient-derived cells and tissues.
Thu Nov 04 00:00:00 UTC 2021
The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export.
The Journal of biological chemistry
Wilson MS,Jessen HJ,Saiardi A
45-8199 was used in Western Blotting to show that IP6K1 and -2 together control inositol pyrophosphate metabolism and thereby physiologically regulate phosphate export and other aspects of mammalian cellular phosphate homeostasis.
Fri Jul 26 00:00:00 UTC 2019
Impairment of Mitochondrial Redox Status in Peripheral Lymphocytes of Multiple Sclerosis Patients.
Frontiers in neuroscience
Gonzalo H,Nogueras L,Gil-Sánchez A,Hervás JV,Valcheva P,González-Mingot C,Martin-Gari M,Canudes M,Peralta S,Solana MJ,Pamplona R,Portero-Otin M,Boada J,Serrano JCE,Brieva L
45-8199 was used in Western Blotting to explore the influence of oxidative stress in peripheral lymphocytes of MS patients.
Wed Sep 30 00:00:00 UTC 2020
Mice overexpressing chromogranin A display hypergranulogenic adrenal glands with attenuated ATP levels contributing to the hypertensive phenotype.
Journal of hypertension
Mir SA,Li Y,Story JD,Bal S,Awdishu L,Street AA,Mehta RL,Singh P,Vaingankar SM
45-8199 was used in Western Blotting to show that overexpression of chromogranin A (CHGA) in mouse adrenal glands leads to biochemical changes that contribute to the hypertensive phenotype type.
Tue May 01 00:00:00 UTC 2018
Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner Ear.
Antioxidants & redox signaling
Tan WJT,Song L,Graham M,Schettino A,Navaratnam D,Yarbrough WG,Santos-Sacchi J,Ivanova AV
45-8199 was used in Western Blotting to study the mechanisms of mitochondria-dependent hearing loss Fus1 knock-out mice.
Sun Sep 10 00:00:00 UTC 2017
Mitochondrial function in skeletal muscle of patients with protracted critical illness and ICU-acquired weakness.
Critical care (London, England)
Jiroutková K,Krajčová A,Ziak J,Fric M,Waldauf P,Džupa V,Gojda J,Němcova-Fürstová V,Kovář J,Elkalaf M,Trnka J,Duška F
45-8199 was used in western blot to characterize patients with protracted critical illness and ICU-acquired weakness by studying mitochondrial function in skeletal muscle
Thu Dec 24 00:00:00 UTC 2015
