Product References
Proteasome inhibition protects blood-brain barrier P-glycoprotein and lowers Aβ brain levels in an Alzheimer's disease model.
Fluids and barriers of the CNS
Vulin M,Zhong Y,Maloney BJ,Bauer B,Hartz AMS
MA1-26528 was used in Western Blot to suggest that the proteasome system could be exploited for a novel therapeutic strategy in Alzheimer's disease (AD), particularly since increasing Aβ transport across the blood-brain barrier may prove an effective treatment for patients.
Fri Oct 06 00:00:00 UTC 2023
Triple combination of lomustine, temozolomide and irradiation reduces canine glioma cell survival in vitro.
Veterinary medicine and science
Fuchs D,Rohrer Bley C,Morandi L,Tonon C,Weyland MS,Nytko KJ
Published figure using P-Glycoprotein monoclonal antibody (Product # MA1-26528) in Western Blot
Sat Jul 01 00:00:00 UTC 2023
Effect of hepatic NPC1L1 on cholesterol gallstone disease and its mechanism.
Heliyon
Mo P,Chen H,Jiang X,Hu F,Zhang F,Shan G,Chen W,Li S,Xu G
MA1-26528 was used in Western Blotting to suggest that hepatic NPC1L1 is unable to prevent CGD, whereas EZE functions as an efficient bile cholesterol desaturator during CGD development.
Mon May 01 00:00:00 UTC 2023
Functional Blood-Brain Barrier Model with Tight Connected Minitissue by Liquid Substrates Culture.
Advanced healthcare materials
Liu N,Zhu Y,Yu K,Gu Z,Lv S,Chen Y,He C,Fu J,He Y
MA1-26528 was used in Immunocytochemistry to present a new blood-brain barrier (BBB) model with a high-cell spatial density and tightly connected biomimetic minitissue.
Wed Feb 01 00:00:00 UTC 2023
Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and Ultrastructural Study in the Rat Liver.
Cells
Gericke B,Wienböker I,Brandes G,Löscher W
MA1-26528 was used in Western Blotting to demonstrate the importance of combining biochemical and ultrastructural methods to investigate the relationship between Pgp localization and function.
Thu May 05 00:00:00 UTC 2022
Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and Ultrastructural Study in the Rat Liver.
Cells
Gericke B,Wienböker I,Brandes G,Löscher W
MA1-26528 was used in Western Blotting to demonstrate the importance of combining biochemical and ultrastructural methods to investigate the relationship between Pgp localization and function.
Thu May 05 00:00:00 UTC 2022
A human kidney and liver organoid-based multi-organ-on-a-chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell-derived extracellular vesicles.
Journal of extracellular vesicles
Nguyen VVT,Ye S,Gkouzioti V,van Wolferen ME,Yengej FY,Melkert D,Siti S,de Jong B,Besseling PJ,Spee B,van der Laan LJW,Horland R,Verhaar MC,van Balkom BWM
MA1-26528 was used in Immunohistochemistry to develop a multi-organ-on-a-chip (MOC) model that combines human kidney and liver organoids connected by microfluidic channels to study the therapeutic effects and biodistribution of mesenchymal stromal cell-derived small extracellular vesicles (MSC-sEVs).
Tue Nov 01 00:00:00 UTC 2022
Essential Oils, Pituranthos chloranthus and Teucrium ramosissimum, Chemosensitize Resistant Human Uterine Sarcoma MES-SA/Dx5 Cells to Doxorubicin by Inducing Apoptosis and Targeting P-Glycoprotein.
Nutrients
Lahmar A,Mathey A,Aires V,Elgueder D,Vejux A,Khlifi R,Sioud F,Chekir-Ghedira L,Delmas D
Published figure using P-Glycoprotein monoclonal antibody (Product # MA1-26528) in Western Blot
Wed May 19 00:00:00 UTC 2021
Protecting P-glycoprotein at the blood-brain barrier from degradation in an Alzheimer's disease mouse model.
Fluids and barriers of the CNS
Ding Y,Zhong Y,Baldeshwiler A,Abner EL,Bauer B,Hartz AMS
MA1-26528 was used in Western Blot to investigate if microtubule inhibition maintains P-glycoprotein protein expression and transport activity levels, and if it helps to lower hAβ brain levels in human amyloid precursor protein mice.
Sat Mar 06 00:00:00 UTC 2021
Protecting P-glycoprotein at the blood-brain barrier from degradation in an Alzheimer's disease mouse model.
Fluids and barriers of the CNS
Ding Y,Zhong Y,Baldeshwiler A,Abner EL,Bauer B,Hartz AMS
MA1-26528 was used in Western Blot to investigate if microtubule inhibition maintains P-glycoprotein protein expression and transport activity levels, and if it helps to lower hAβ brain levels in human amyloid precursor protein mice.
Sat Mar 06 00:00:00 UTC 2021
Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents.
Journal of medicinal chemistry
Chen H,Deng S,Albadari N,Yun MK,Zhang S,Li Y,Ma D,Parke DN,Yang L,Seagroves TN,White SW,Miller DD,Li W
MA1-26528 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to show that tubulin inhibitor CH-2-77 analogue 60c is a promising lead compound for further development as a potential anticancer agent.
Thu Aug 26 00:00:00 UTC 2021
Vascularized human cortical organoids (vOrganoids) model cortical development in vivo.
PLoS biology
Shi Y,Sun L,Wang M,Liu J,Zhong S,Li R,Li P,Guo L,Fang A,Chen R,Ge WP,Wu Q,Wang X
Published figure using P-Glycoprotein monoclonal antibody (Product # MA1-26528) in Immunocytochemistry
Fri May 01 00:00:00 UTC 2020
APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease.
Neurobiology of disease
Lin AL,Parikh I,Yanckello LM,White RS,Hartz AMS,Taylor CE,McCulloch SD,Thalman SW,Xia M,McCarty K,Ubele M,Head E,Hyder F,Sanganahalli BG
MA1-26528 was used in Western Blotting to indicate that rapamycin was able to restore brain functions and reduce AD risk for young, asymptomatic E4FAD mice, and there were pharmacogenetic differences between the E3FAD and E4FAD mice.
Mon Jun 01 00:00:00 UTC 2020
An Orally Available Tubulin Inhibitor, VERU-111, Suppresses Triple-Negative Breast Cancer Tumor Growth and Metastasis and Bypasses Taxane Resistance.
Molecular cancer therapeutics
Deng S,Krutilina RI,Wang Q,Lin Z,Parke DN,Playa HC,Chen H,Miller DD,Seagroves TN,Li W
MA1-26528 was used in Western Blotting to demonstrate the efficacy of VERU-111 in vivo and provide strong rationale for future development of VERU-111 as an effective treatment for metastatic breast cancer.
Sat Feb 01 00:00:00 UTC 2020
ABC transporters in gills of rainbow trout (Oncorhynchus mykiss).
The Journal of experimental biology
Kropf C,Fent K,Fischer S,Casanova A,Segner H
MA1-26528 was used in Immunocytochemistry to investigate the presence, diversity and functional activity of ATP-binding cassette (ABC) transporters in gills of juvenile rainbow trout.
Tue Aug 11 00:00:00 UTC 2020
The potential role of human multidrug resistance protein 1 (MDR1) and multidrug resistance-associated protein 2 (MRP2) in the transport of Huperzine A in vitro.
Xenobiotica; the fate of foreign compounds in biological systems
Fei Z,Hu M,Baum L,Kwan P,Hong T,Zhang C
Published figure using P-Glycoprotein monoclonal antibody (Product # MA1-26528) in Western Blot
Sun Mar 01 00:00:00 UTC 2020
Orally available tubulin inhibitor VERU-111 enhances antitumor efficacy in paclitaxel-resistant lung cancer.
Cancer letters
Mahmud F,Deng S,Chen H,Miller DD,Li W
MA1-26528 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to show that VERU-111 is a promising new generation of anti-tubulin agent for the treatment of taxane-resistant lung cancer.
Mon Dec 28 00:00:00 UTC 2020
P-glycoprotein Expression Is Upregulated in a Pre-Clinical Model of Traumatic Brain Injury.
Neurotrauma reports
Vita SM,Redell JB,Maynard ME,Zhao J,Grill RJ,Dash PK,Grayson BE
MA1-26528 was used in Immunohistochemistry to suggest that increased expression of Pgp after rmCHI may reduce the brain accumulation of therapeutic drugs that are Pgp substrates.
Thu Nov 11 00:00:00 UTC 2021
Porphyrin-lipid assemblies and nanovesicles overcome ABC transporter-mediated photodynamic therapy resistance in cancer cells.
Cancer letters
Baglo Y,Liang BJ,Robey RW,Ambudkar SV,Gottesman MM,Huang HC
MA1-26528 was used in Western Blotting to investigate the role of P-glycoprotein in benzoporphyrin derivative transport and BPD-PDT resistance.
Sat Aug 10 00:00:00 UTC 2019
Inhibition of human microsomal PGE2 synthase-1 reduces seizure-induced increases of P-glycoprotein expression and activity at the blood-brain barrier.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Soldner ELB,Hartz AMS,Akanuma SI,Pekcec A,Doods H,Kryscio RJ,Hosoya KI,Bauer B
MA1-26528 was used in Western Blot to provide key signaling steps underlying seizure-induced P-gp up-regulation and suggest that mPGES-1 inhibitors could potentially prevent P-gp up-regulation in epilepsy.-Soldner, E. L. B., Hartz, A. M. S., Akanuma, S.-I., Pekcec, A., Doods, H., Kryscio, R. J., Hosoya, K.-I., Bauer, B. Inhibition of human microsomal PGE2 synthase-1 reduces seizure-induced increases of P-glycoprotein expression and activity at the blood-brain barrier.
Sun Dec 01 00:00:00 UTC 2019
Cytosolic phospholipase A2 is a key regulator of blood-brain barrier function in epilepsy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Hartz AMS,Rempe RG,Soldner ELB,Pekcec A,Schlichtiger J,Kryscio R,Bauer B
MA1-26528 was used in Western Blot to demonstrate, in vivo, that cPLA2 inhibition prevents overexpression of P-gp and BCRP at the blood-brain barrier in rats after status epilepticus and in CE rats.
Sun Dec 01 00:00:00 UTC 2019
Preventing P-gp Ubiquitination Lowers Aβ Brain Levels in an Alzheimer's Disease Mouse Model.
Frontiers in aging neuroscience
Hartz AMS,Zhong Y,Shen AN,Abner EL,Bauer B
Published figure using P-Glycoprotein monoclonal antibody (Product # MA1-26528) in Immunofluorescence
Tue Dec 08 00:00:00 UTC 2020
Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice.
Scientific reports
Ma D,Wang AC,Parikh I,Green SJ,Hoffman JD,Chlipala G,Murphy MP,Sokola BS,Bauer B,Hartz AMS,Lin AL
Published figure using P-Glycoprotein monoclonal antibody (Product # MA1-26528) in Western Blot
Fri Apr 27 00:00:00 UTC 2018
Establishment and characterization of arsenic trioxide resistant KB/ATO cells.
Acta pharmaceutica Sinica. B
Zhang YK,Dai C,Yuan CG,Wu HC,Xiao Z,Lei ZN,Yang DH,Le XC,Fu L,Chen ZS
Published figure using P-Glycoprotein monoclonal antibody (Product # MA1-26528) in Western Blot
Fri Sep 01 00:00:00 UTC 2017
Age Drives Distortion of Brain Metabolic, Vascular and Cognitive Functions, and the Gut Microbiome.
Frontiers in aging neuroscience
Hoffman JD,Parikh I,Green SJ,Chlipala G,Mohney RP,Keaton M,Bauer B,Hartz AMS,Lin AL
MA1-26528 was used in Western Blotting to determine the contribution of ageing processes to Alzheimer's disease aetiology.
Tue Aug 08 00:00:00 UTC 2023
Molecular Imaging of P-glycoprotein in Chemoresistant Tumors Using a Dual-Modality PET/Fluorescence Probe.
Molecular pharmaceutics
Wang M,Mao C,Wang H,Ling X,Wu Z,Li Z,Ming X
MA1-26528 was used in Immunohistochemistry to develop a molecularly targeted probe for imaging tumoural Pgp in vivo with positron emission tomography and fluorescence, and provide a tool for preselecting the patients with tumoral Pgp expression.
Mon Oct 02 00:00:00 UTC 2017
Selective induction of P-glycoprotein at the CNS barriers during symptomatic stage of an ALS animal model.
Neuroscience letters
Chan GN,Evans RA,Banks DB,Mesev EV,Miller DS,Cannon RE
MA1-26528 was used in Immunohistochemistry-immunofluorescence to mply that novel pharmacological approaches for treating ALS require selecting drugs that are not P-gp substrates in order to improve therapeutic efficacy in the CNS during ALS progression.
Fri Feb 03 00:00:00 UTC 2017
A multifunctional lipid nanoparticle for co-delivery of paclitaxel and curcumin for targeted delivery and enhanced cytotoxicity in multidrug resistant breast cancer cells.
Oncotarget
Baek JS,Cho CW
MA1-26528 was used in Western Blotting to develop a nanoparticle that effectively releases both paclitaxel and curcumin, showing enhanced cytotoxicity and cellular uptake in in multidrug resistant breast cancer cells.
Tue May 02 00:00:00 UTC 2017
Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.
The Journal of biological chemistry
Esser L,Zhou F,Pluchino KM,Shiloach J,Ma J,Tang WK,Gutierrez C,Zhang A,Shukla S,Madigan JP,Zhou T,Kwong PD,Ambudkar SV,Gottesman MM,Xia D
MA126528 was used in western blot to generate a shortened mutant allele of P-glycoprotein to determine its structure
Fri Jan 13 00:00:00 UTC 2017
Aβ40 Reduces P-Glycoprotein at the Blood-Brain Barrier through the Ubiquitin-Proteasome Pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hartz AM,Zhong Y,Wolf A,LeVine H,Miller DS,Bauer B
MA1-26528 was used in Western Blot to identify critical mechanistic steps involved in reducing P-glycoprotein in Alzheimer's disease.
Wed Feb 10 00:00:00 UTC 2016
Inhibition of P-glycoprotein, multidrug resistance-associated protein 2 and cytochrome P450 3A4 improves the oral absorption of octreotide in rats with portal hypertension.
Experimental and therapeutic medicine
Sun XY,Duan ZJ,Liu Z,Tang SX,Li Y,He SC,Wang QM,Chang QY
MA1-26528 was used in immunohistochemistry - frozen section and western blot to develop a method to increase the intestinal transport of octreotide
Thu Dec 01 00:00:00 UTC 2016
Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions.
Aging
Parikh I,Guo J,Chuang KH,Zhong Y,Rempe RG,Hoffman JD,Armstrong R,Bauer B,Hartz AM,Lin AL
MA126528 was used in western blot to assess the effect of caloric restriction on neurovascular functions
Tue Nov 08 00:00:00 UTC 2016
Reversal of multidrug resistance phenotype in human breast cancer cells using doxorubicin-liposome-microbubble complexes assisted by ultrasound.
Journal of controlled release : official journal of the Controlled Release Society
Deng Z,Yan F,Jin Q,Li F,Wu J,Liu X,Zheng H
MA1-26528 was used in western blot to study the ability of novel doxorubicin liposome complexes plus ultrasound to overcome the multidrug resistance of human breast cancer cells
Tue Jan 28 00:00:00 UTC 2014
Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function.
Cancer letters
Katayama K,Yamaguchi M,Noguchi K,Sugimoto Y
MA1-26528 was used in western blot to investigate the relationship between PP5/PPP2R3C and P-gp
Tue Apr 01 00:00:00 UTC 2014
P-gp efflux pump inhibition potential of common environmental contaminants determined in vitro.
Environmental toxicology and chemistry
Georgantzopoulou A,Skoczyńska E,Van den Berg JH,Brand W,Legay S,Klein SG,Rietjens IM,Murk AJ
MA1-26528 was used in immunocytochemistry to study the ability of common aquatic environmental contaminants to inhibit MDR-1
Tue Apr 01 00:00:00 UTC 2014
Instruction of circulating endothelial progenitors in vitro towards specialized blood-brain barrier and arterial phenotypes.
PloS one
Boyer-Di Ponio J,El-Ayoubi F,Glacial F,Ganeshamoorthy K,Driancourt C,Godet M,Perrière N,Guillevic O,Couraud PO,Uzan G
MA1-26528 was used in western blot to study cord blood as a source of circulating endothelial progenitor cells that can be directed towards specialized endothelial phenotypes
Tue Nov 18 00:00:00 UTC 2014