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P2RY1 Antibody (OSP00119W-100UL) in IHC (P)
IHC on paraffin sections of rat kidney tissue using Rabbit antibody to P2RY1:OSP00119W. HIER: 1 mM EDTA, pH 8 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions. Primary antibody: dilution 1:1000, incubated 30 min at RT (using Autostainer). Sections were counterstained with Harris ... View More
Product Details
OSP00119W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Guinea pig,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from the c-terminal region of mouse P2Y1 (P2RY1) conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: P2RY1.
Target Information
P2Y1 is a Purinergic Receptor that causes a change in platelet shape and potentially leads to platelet aggregation by binding ADP, which results in the mobilization of intracellular calcium ions via activation of phospholipase C. This receptor also mediates the release of the relaxing factor nitric oxide and may be involved in the modulation of neuronal signal transmission. P2Y1 has been reported to be expressed in tissues throughout the body, particularly brain. ESTs have been isolated from human embryo, lung, and placenta libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ADP receptor; ATP receptor; membrane protein; P2 purinoreceptor subclass 2Y; P2Y ATP receptor 1; P2Y purinoceptor 1; p2y-1-r; P2Y1; P2Y1 purinoceptor; P2Y1 receptor; p2y1r; Purinergic receptor; purinergic receptor P2Y, G-protein coupled 1; Purinoceptor p2y1; Purinoceptor p2yr1
Gene Aliases: P2RY1; P2y; P2Y1
UniProt ID: (Rat) P49651, (Guinea pig) P59902, (Mouse) P49650
Entrez Gene ID: (Rat) 25265, (Guinea pig) 100135592, (Mouse) 18441
ATP binding
A1 adenosine receptor binding
ADP binding
G-protein coupled purinergic nucleotide receptor activity
ATP-activated adenosine receptor activity
ADP-activated adenosine receptor activity
protein heterodimerization activity
scaffold protein binding
signal transducer activity
G-protein coupled receptor activity
G-protein coupled receptor
positive regulation of protein phosphorylation
adenosine receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
aging
glial cell migration
response to mechanical stimulus
regulation of receptor activity
negative regulation of norepinephrine secretion
sensory perception of pain
signal transduction involved in regulation of gene expression
platelet activation
positive regulation of inositol trisphosphate biosynthetic process
G-protein coupled purinergic nucleotide receptor signaling pathway
wound healing
regulation of vasodilation
eating behavior
positive regulation of ion transport
positive regulation of transcription from RNA polymerase II promoter
positive regulation of hormone secretion
negative regulation of binding
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
positive regulation of penile erection
positive regulation of ERK1 and ERK2 cascade
response to growth factor
cellular response to organic cyclic compound
protein localization to plasma membrane
relaxation of muscle
signal transduction
phospholipase C-activating G-protein coupled receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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