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P2X3 Antibody (PA5-115707) in ICC/IF
Immunocytochemistry analysis of P2X3 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115707) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
产品信息
PA5-115707
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human P2RX3(Accession P56373), corresponding to amino acid residues D379-H397.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900342
产品详细信息
Antibody detects endogenous levels of total P2X3.
靶标信息
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP receptor; MGC129956; P2X purinoceptor 3; p2X receptor 3; P2X receptor, subunit 3; P2X3; p2X3 purinoceptor; p2xr3; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 3; purinergic receptor P2X, ligand-gated ion channel, 3; purinergic receptor P2X3; purinoceptor P2X3
基因别名: 4930513E20Rik; P2RX3; P2X3
UniProt ID: (Human) P56373, (Rat) P49654, (Mouse) Q3UR32
Entrez Gene ID: (Human) 5024, (Rat) 81739, (Mouse) 228139
response to hypoxia
transport
signal transduction
neuromuscular synaptic transmission
blood coagulation
response to heat
response to cold
response to mechanical stimulus
response to carbohydrate
positive regulation of calcium ion transport into cytosol
urinary bladder smooth muscle contraction
neuronal action potential
peristalsis
response to ATP
purinergic nucleotide receptor signaling pathway
regulation of synaptic plasticity
positive regulation of calcium-mediated signaling
sensory perception of taste
protein homooligomerization
behavioral response to formalin induced pain
cation transmembrane transport
positive regulation of sensory perception of pain
ion transport
cation transport
chemical synaptic transmission
response to temperature stimulus
response to organic substance
behavioral response to pain
