Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 5
P2Y6 Receptor (extracellular) Antibody (APR-106-200UL) in IHC (F)
Expression of P2RY6 in rat parietal cortex - Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Anti-P2Y6 Receptor (extracellular) Antibody (#APR-106), (1:1000), followed by donkey- Anti-rabbit-biotin and streptavidin-Cy3. P2RY6 immunoreactivity (red) appears in pyramidal neurons (arrows). Cell nuclei are stained with DAPI (blue).
Product Details
APR-106-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)RNRTV(S)YDLSPPILS, corresponding to amino acid residues 172-186 of mouse P2RY6, 2nd extracellular loop
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
Target Information
P2Y6 belongs to the family of G protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. P2Y6 expression has been documented in various blood cells, bone marrow, brain, colon, heart, kidney, ovary, placenta, spleen and thymus. ESTs have been isolated from cervix, embryo, eye, kidney, liver/spleen, placenta, and vessel libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: G-coupled nucleotide receptor; MGC15335; P2 purinoceptor; P2Y ATP receptor 6; P2Y purinoceptor 6; p2y3 and chick; p2y3 receptor; P2Y6; P2Y6 receptor; Purinoceptor p2y6; pyrimidinergic receptor P2Y, G-protein coupled, 6
Gene Aliases: 2010204J23Rik; P2RY6; P2Y6; PP2891
UniProt ID: (Human) Q15077, (Rat) Q63371, (Mouse) Q9ERK9
Entrez Gene ID: (Human) 5031, (Rat) 117264, (Mouse) 233571
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of smooth muscle cell migration
transepithelial chloride transport
G-protein coupled purinergic nucleotide receptor signaling pathway
cellular response to prostaglandin E stimulus
cellular response to organic cyclic compound
G-protein coupled receptor signaling pathway
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support