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PACAP-38 Antibody (PA5-143860) in IHC (P)
Immunohistochemistry analysis of PACAP-38 in paraffin-embedded section of human lung cancer tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. Samples were incubated with PACAP-38 Polyclonal antibody (Product # PA5-143860) using a dilution of 2 μg/mL overnight at 4°C. Biotinylated goat anti-rabbit IgG... View More
产品信息
PA5-143860
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence of human PACAP-38/ADCYAP1 (QMAVKKYLAAVLGKRYKQRVK).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3075074
产品详细信息
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
靶标信息
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adenylate cyclase activating polypeptide 1 (pituitary); PACAP; pituitary adenylate cyclase activating polypeptide; Pituitary adenylate cyclase-activating polypeptide; prepro-PACAP
基因别名: ADCYAP1; PACAP
UniProt ID: (Human) P18509
Entrez Gene ID: (Human) 116
ovarian follicle development
behavioral fear response
histamine secretion
negative regulation of acute inflammatory response to antigenic stimulus
negative regulation of acute inflammatory response to non-antigenic stimulus
activation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
cell-cell signaling
female pregnancy
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of cell proliferation
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
negative regulation of muscle cell apoptotic process
positive regulation of neuron projection development
sensory perception of pain
cAMP-mediated signaling
pituitary gland development
neuron projection development
positive regulation of interleukin-6 production
regulation of protein localization
negative regulation of GTPase activity
response to starvation
negative regulation of potassium ion transport
positive regulation of GTPase activity
response to ethanol
negative regulation of cell cycle
positive regulation of protein kinase activity
positive regulation of vasodilation
positive regulation of transcription from RNA polymerase II promoter
ATP metabolic process
positive regulation of synaptic transmission, glutamatergic
regulation of postsynaptic membrane potential
positive regulation of growth hormone secretion
negative regulation of glial cell proliferation
positive regulation of ERK1 and ERK2 cascade
regulation of oligodendrocyte progenitor proliferation
cellular response to glucocorticoid stimulus
positive regulation of chemokine (C-C motif) ligand 5 production
positive regulation of somatostatin secretion
