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PACAP Receptor 1 (PAC1) Antibody (AVR-003-200UL) in IHC (F)
Expression ofPAC1 receptor in rat cerebellum - Immunohistochemical staining of perfusion-fixed frozen rat brain sections using Anti-PACAP Receptor 1 (PAC1) Antibody (#AVR-003), (1:400), followed by donkey Anti-rabbit-Cy3 Antibody .PAC1 receptor staining (red)appears in Purkinje cells (arrows). Nuclei are stained with DAPI (blue).
产品信息
AVR-003-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)KVNRYFTMDFKHRH, corresponding to amino acid residues 474-487 of rat PAC1 receptor, Intracellular, C-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Alternative splicing of two exons of this gene generates four major splice variants, but their full-length nature has not been determined. PACAP receptor type 1 expression has been documented in adipose, adrenal, bone, brain, colon, ganglion, heart, lung, ovary, pancreas, placenta, spleen, and uterus. ESTs have been isolated from brain and nerve libraries.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ADCYAP1 R1; ADCYAP1R 1; adenylate cyclase activating polypeptide 1 (pituitary) receptor type I; adenylate cyclase activating polypeptide 1 type 1 receptor; PAC 1; PAC1 receptor; Pac1 receptors; PACAP R 1; PACAP Receptor; PACAP type I receptor; PACAP type IA receptor; PACAP-R-1; PACAP-R-1A; PACAP/VIP receptors; PACAP1 R; PACAP1 receptor; pituitary adenylate cyclase activating polypeptide 1 receptor (1); pituitary adenylate cyclase activating polypeptide receptor; Pituitary adenylate cyclase-activating polypeptide type I receptor; pituitary adenylate cyclase-activating polypeptide type IA receptor; pvr1
基因别名: 2900024I10Rik; Adcyap1r1; AI846590; PAC1; PAC1-R; PAC1R; PACAP-R1; PACAP-R1A; PACAP1-R; PACAPR1; PACAPR1A
UniProt ID: (Mouse) P70205, (Rat) P32215
Entrez Gene ID: (Mouse) 11517, (Rat) 24167
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
activation of phospholipase C activity
multicellular organism development
spermatogenesis
positive regulation of calcium ion transport into cytosol
cAMP-mediated signaling
cell differentiation
positive regulation of cAMP biosynthetic process
negative regulation of cell death
positive regulation of inositol phosphate biosynthetic process
response to estradiol
multicellular organismal response to stress
response to drug
response to ethanol
development of primary female sexual characteristics
