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产品信息
PA5-110070
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 290-663 of human PADI4 (NP_0365192)
偶联物
形式
Liquid
浓度
2.08 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2855481
产品详细信息
Immunogen sequence: VFRVAPWIMT PNTQPPQEVY ACSIFENEDF LKSVTTLAMK AKCKLTICPE EENMDDQWMQ DEMEIGYIQA PHKTLPVVFD SPRNRGLKEF PIKRVMGPDF GYVTRGPQTG GISGLDSFGN LEVSPPVTVR GKEYPLGRIL FGDSCYPSND SRQMHQALQD FLSAQQVQAP VKLYSDWLSV GHVDEFLSFV PAPDRKGFRL LLASPRSCYK LFQEQQNEGH GEALLFEGIK KKKQQKIKNI LSNKTLREHN SFVERCIDWN RELLKRELGL AESDIIDIPQ LFKLKEFSKA EAFFPNMVNM LVLGKHLGIP KPFGPVINGR CCLEEKVCSL LEPLGLQCTF INDFFTYHIR HGEVHCGTNV RRKPFSFKWW NMVP
靶标信息
Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HL-60 PAD; PAD type IV; PAD-R4; PADI-H protein; peptidyl arginine deiminase, type 4; peptidyl arginine deiminase, type IV; peptidyl arginine deiminase, type V; Peptidylarginine deiminase IV; Peptidylarginine deiminase type alpha; Protein-arginine deiminase type IV; Protein-arginine deiminase type-4
基因别名: PAD; PAD4; PADI4; PADI5; PDI4; PDI5
UniProt ID: (Human) Q9UM07, (Rat) O88807, (Mouse) Q9Z183
Entrez Gene ID: (Human) 23569, (Rat) 29512, (Mouse) 18602
chromatin organization
nucleosome assembly
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular protein modification process
chromatin modification
protein citrullination
stem cell population maintenance
histone H3-R26 citrullination
histone citrullination
innate immune response
immune system process
