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Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: MGC72018; PABC1-interacting protein 2; PABP-interacting protein 2; PAIP-2; poly(A)-binding protein-interacting protein 2; polyA-binding protein-interacting protein 2; Polyadenylate-binding protein-interacting protein 2
基因别名: 2310050K10Rik; AU045972; HSPC218; PAIP-2; PAIP2; PAIP2A
UniProt ID: (Human) Q9BPZ3, (Mouse) Q9D6V8
Entrez Gene ID: (Human) 51247, (Mouse) 67869