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PAK1 Antibody (PA5-29224) in IHC (P)
PAK1 Polyclonal Antibody detects PAK1 protein at cytosol and membrane on mouse fore brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse fore brain. PAK1 Polyclonal Antibody (Product # PA5-29224) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-29224
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 167 and 436 of Human PAK1
偶联物
形式
Liquid
浓度
0.84 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2546700
产品详细信息
Recommended positive controls: A431, BCL-1, PC-12, SH-SY5Y.
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (94%), Xenopus laevis (87%), Chicken (95%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
PAK1 is a serine/threonine kinase that is a target for restenosis, cancer, and immunosuppression treatment. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: activated protein kinase alpha; ADRB2; alpha pak; Alpha-PAK; CDC42/RAC effector kinase PAK-A; EC 2.7.11.1; kinase PAK1; MGC130000; MGC130001; p21 (CDKN1A)-activated kinase 1; p21 protein (Cdc42/Rac)-activated kinase 1; p21-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p65-PAK; p68-PAK; PAK 1; PAK-1; PAK1B; Protein kinase MUK2; Serine/threonine-protein kinase PAK 1; STE20 homolog, yeast
基因别名: AW045634; PAK-1; PAK1; Paka; PAKalpha
UniProt ID: (Human) Q13153, (Rat) P35465
Entrez Gene ID: (Human) 5058, (Mouse) 18479, (Rat) 29431
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
collagen binding
ATP binding
protein kinase binding
nucleotide binding
catalytic activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Rac GTPase binding
MAP kinase kinase kinase activity
response to hypoxia
positive regulation of protein phosphorylation
protein phosphorylation
exocytosis
apoptotic process
Rho protein signal transduction
regulation of mitotic cell cycle
neuromuscular junction development
metabolic process
response to organic substance
regulation of gene expression
phosphorylation
dendrite development
cell migration
amygdala development
signal transduction by protein phosphorylation
actin cytoskeleton organization
stress-activated protein kinase signaling cascade
actin cytoskeleton reorganization
activation of protein kinase activity
cellular response to insulin stimulus
regulation of actin cytoskeleton organization
positive regulation of peptidyl-serine phosphorylation
positive regulation of intracellular estrogen receptor signaling pathway
wound healing
regulation of apoptotic process
receptor clustering
regulation of MAPK cascade
positive regulation of JUN kinase activity
protein autophosphorylation
branching morphogenesis of an epithelial tube
neuron projection morphogenesis
positive regulation of stress fiber assembly
negative regulation of cell proliferation involved in contact inhibition
dendritic spine development
gamma-aminobutyric acid secretion, neurotransmission
glutamate secretion, neurotransmission
cellular response to organic cyclic compound
observational learning
regulation of long-term synaptic potentiation
MAPK cascade
mitotic cell cycle
stimulatory C-type lectin receptor signaling pathway
axonogenesis
positive regulation of cell proliferation
positive regulation of cell migration
T cell costimulation
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
ephrin receptor signaling pathway
T cell receptor signaling pathway
activation of MAPKK activity
small GTPase mediated signal transduction
intracellular signal transduction
