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产品信息
PA5-52563
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2645193
产品详细信息
Immunogen sequence: SLHTVFCATG GGAYKFEQDF LTIGDLQLCK LDELDCLIKG ILYIDSVGFN GRSQCYYFEN PADSEKCQKL PFDLKNPYPL LLVNIGSGVS ILAVYSKDNY KRVTGT
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
靶标信息
Pantothenate kinase is an essential regulatory enzyme in CoA biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine, and pantetheine. CoA is the major acyl carrier, playing a central role in intermediary and fatty acid metabolism. In both yeast and fly, each with only 1 pantothenate kinase gene, the null mutant is inviable. Mutations in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS). PKAN is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Mutations in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Hallervorden-Spatz syndrome; hPanK2; Pantothenate kinase 2, mitochondrial; Pantothenic acid kinase 2
基因别名: C20orf48; HARP; HSS; NBIA1; PANK2; PKAN
UniProt ID: (Human) Q9BZ23
Entrez Gene ID: (Human) 80025
spermatid development
aerobic respiration
coenzyme biosynthetic process
coenzyme A biosynthetic process
pantothenate metabolic process
phosphorylation
regulation of fatty acid metabolic process
regulation of mitochondrial membrane potential
mitochondrion morphogenesis
regulation of triglyceride metabolic process
regulation of bile acid metabolic process
