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Product Details
H00196743-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PAOX (ABM85423.1, 1 a.a. approximately 511 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MESTGSVGEA PGGPRVLVVG GGIAGLGAAQ RLCGHSAFPH LRVLEATARA GGRIRSERCF GGVVEVGAHW IHGPSRGNPV FQLAAEYGLL GEKELSQENQ LVETGGHVGL PSVSYASSGA SVSLQLVAEM ATLFYGLIDQ TREFLHAAET PVPSVGEYLK KEIGQHVAGW TEDEETRKLK LAVLNSFFNL ECCVSGTHSM DLVALAPFGE YTVLPGLDCT FSKGYQGLTN CMMAALPEDT VVFEKPVKTI HWNGSFQEAA FPGETFPVSV ECEDGDRFPA HHVIVTVPLG FLREHLDTFF DPPLPAEKAE AIRKIGFGTN NKIFLEFEEP FWEPDCQLIQ LVWEDTSPLE DAAPELQDAW FRKLIGFVVL PAFASVHVLC GFIAGLESEF METLSDEEVL LCLTQVLRRV TGNPRLPAPK SVLRSRWHSA PYTRGSYSYV AVGSTGGDLD LLAQPLPADG AGAQLQILFA GEATHRTFYS TTHGALLSGW READRLLSLW APQVQQPRPR L
Target Information
Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12477380). Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs (PubMed:12477380). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Peroxisomal N(1)-acetyl-spermine/spermidine oxidase; peroxisomal N1-acetyl-spermine/spermidine oxidase; Polyamine oxidase
Gene Aliases: PAO; PAOX; UNQ1923/PRO4398
UniProt ID: (Human) Q6QHG6
Entrez Gene ID: (Human) 196743
receptor binding
polyamine oxidase activity
N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
spermine:oxygen oxidoreductase (spermidine-forming) activity
spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity
N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
oxidase
Performance Guarantee
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