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PAOX Antibody (PA5-25758) in IHC (P)
Immunohistochemistry analysis of PAOX in formalin fixed and paraffin embedded human testis tissue. Samples were incubated with PAOX polyclonal antibody (Product # PA5-25758) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-25758
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 467-496 amino acids from the central region of human PAOX
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2543258
Target Information
Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12477380). Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs (PubMed:12477380). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: exo-N4-amino; Peroxisomal N(1)-acetyl-spermine/spermidine oxidase; peroxisomal N1-acetyl-spermine/spermidine oxidase; Polyamine oxidase
Gene Aliases: 2410012F02Rik; AI118225; PAO; PAOX; UNQ1923/PRO4398
UniProt ID: (Human) Q6QHF9, (Mouse) Q8C0L6
Entrez Gene ID: (Human) 196743, (Mouse) 212503
receptor binding
polyamine oxidase activity
N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
spermine:oxygen oxidoreductase (spermidine-forming) activity
spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity
N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
oxidoreductase activity
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