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Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12477380). Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs (PubMed:12477380). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: exo-N4-amino; Peroxisomal N(1)-acetyl-spermine/spermidine oxidase; peroxisomal N1-acetyl-spermine/spermidine oxidase; Polyamine oxidase
基因别名: 2410012F02Rik; AI118225; PAO; PAOX; UNQ1923/PRO4398
UniProt ID: (Human) Q6QHF9, (Mouse) Q8C0L6
Entrez Gene ID: (Human) 196743, (Mouse) 212503