Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 5
PAR1 (F2R) (extracellular) Antibody (APR-031-200UL) in ICC/IF
Expression of PAR-1 in human prostate PC-3 cell line - Cell surface detection of PAR-1 in human prostate PC-3 cell line. A.Live intact PC-3 cells were stained with Anti-Human PAR1 (F2R) (extracellular) Antibody (#APR-031), (1:50), followed by goat- Anti-rabbit-AlexaFluor-555 secondary Antibody (red staining). Nuclei were visualized using the cell-permeable dye Hoechst 33342 (blue). B. Live view of the same ... View More
产品信息
APR-031-200UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)KNESGLTEYRLVSINK, corresponding to amino acid residues 61-76 of human PAR-1, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Thrombin is a serine protease that is involved in platelet aggregation and blood coagulation. It is cleaved from its precursor, prothrombin, and converts fibrinogen to fibrin in the final step of the clotting cascade. Thrombin mediates its regulatory effects by activating cell surface G-protein coupled receptors which include PAR-1, PAR-2 and PAR3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: C HTR; coagulation factor II (thrombin) receptor; Coagulation factor II receptor; PAR-1; protease activated receptor 1; protease-activated receptor 1; Proteinase-activated receptor 1; Thrombin receptor
基因别名: CF2R; F2R; HTR; PAR-1; PAR1; TR
UniProt ID: (Human) P25116
Entrez Gene ID: (Human) 2149
activation of MAPKK activity
connective tissue replacement involved in inflammatory response wound healing
negative regulation of glomerular filtration
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
protein kinase C-activating G-protein coupled receptor signaling pathway
tyrosine phosphorylation of STAT protein
STAT protein import into nucleus
establishment of synaptic specificity at neuromuscular junction
blood coagulation
positive regulation of cell proliferation
negative regulation of cell proliferation
response to wounding
anatomical structure morphogenesis
positive regulation of phosphatidylinositol 3-kinase signaling
platelet activation
regulation of blood coagulation
positive regulation of blood coagulation
positive regulation of cell migration
response to lipopolysaccharide
regulation of interleukin-1 beta production
positive regulation of collagen biosynthetic process
positive regulation of Rho protein signal transduction
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of vasoconstriction
positive regulation of smooth muscle contraction
positive regulation of JAK-STAT cascade
homeostasis of number of cells within a tissue
release of sequestered calcium ion into cytosol
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
positive regulation of calcium ion transport
regulation of sensory perception of pain
platelet dense granule organization
positive regulation of ERK1 and ERK2 cascade
thrombin receptor signaling pathway
negative regulation of renin secretion into blood stream
positive regulation of interleukin-8 secretion
positive regulation of interleukin-6 secretion
