Invitrogen

PAX8 Recombinant Rabbit Monoclonal Antibody (JJ08-88)

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抗体检测数据 (4)

PAX8 Antibody in Immunocytochemistry (ICC/IF)

PAX8 Antibody in Immunocytochemistry (ICC/IF)

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PAX8 Antibody (MA5-32456) in ICC/IF

Immunocytochemical analysis of PAX8 in SKOV-3 cells using a PAX8 Monoclonal antibody (Product # MA5-32456) as seen in green. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

PAX8 Antibody in Immunocytochemistry (ICC/IF)

PAX8 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PAX8 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

PAX8 Antibody in Western Blot (WB)

Product Image Gallery

PAX8 Antibody in Immunocytochemistry (ICC/IF) — Immunocytochemical analysis of PAX8 in SKOV-3 cells using a PAX8 Monoclonal antibody (Product # MA5-32456) as seen in green. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

PAX8 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of PAX8 of paraffin-embedded Human ovarian cancer tissue using a PAX8 Monoclonal antibody (Product #MA5-32456). Counter stained with hematoxylin.

PAX8 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of PAX8 of paraffin-embedded Human thyroid tissue using a PAX8 Monoclonal antibody (Product #MA5-32456). Counter stained with hematoxylin.

PAX8 Antibody in Western Blot (WB) — Western blot analysis of PAX8 in SKOV-3 cells lysates using a PAX8 Monoclonal antibody (Product # MA5-32456) at a dilution of 1:1,000.

产品信息

MA5-32456

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

-

免疫组化（石蜡） (IHC (P))

1:50-1:200

-

免疫细胞化学 (ICC/IF)

1:50-1:200

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

JJ08-88

抗原

Recombinant protein within Human PAX8 aa 101-450

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2809733

产品详细信息

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

靶标信息

This gene encodes a member of the paired box family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: HGNC:8622; Paired box protein Pax-8; paired domain gene 8

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基因别名: PAX8

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UniProt ID: (Human) Q06710

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Entrez Gene ID: (Human) 7849

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RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding thyroid-stimulating hormone receptor activity protein binding transcription regulatory region DNA binding

urogenital system development branching involved in ureteric bud morphogenesis kidney development mesonephros development mesenchymal to epithelial transition involved in metanephros morphogenesis transcription, DNA-templated transcription from RNA polymerase II promoter sulfur compound metabolic process central nervous system development anatomical structure morphogenesis thyroid gland development thyroid-stimulating hormone signaling pathway pronephric field specification inner ear morphogenesis regulation of apoptotic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter pronephros development cellular response to gonadotropin stimulus otic vesicle development positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis metanephric epithelium development metanephric distal convoluted tubule development metanephric comma-shaped body morphogenesis metanephric S-shaped body morphogenesis metanephric nephron tubule formation negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis regulation of metanephric nephron tubule epithelial cell differentiation positive regulation of branching involved in ureteric bud morphogenesis negative regulation of mesenchymal cell apoptotic process involved in metanephros development negative regulation of apoptotic process involved in metanephric collecting duct development negative regulation of apoptotic process involved in metanephric nephron tubule development positive regulation of metanephric DCT cell differentiation positive regulation of thyroid hormone generation regulation of thyroid-stimulating hormone secretion