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PBK Antibody (PA5-79786) in ICC/IF
Immunocytochemistry analysis of PBK using anti-PBK antibody (Product # PA5-79786). PBK was detected in a section of U2OS cells. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum and then incubated with 2μg/mL rabbit anti-PBK antibody (Product # PA5-79786) overnight at 4°C. DyLight®594 Conjugated Goat Anti-Rabbit IgG was used as secondary antibody at 1:100 dilution and incubated for 30 minutes at 37°C. The section was counterstained with DAPI. Visualize ... View More
产品信息
PA5-79786
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human PBK recombinant protein (Position: N71-V322).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2746901
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
PBK (TOPK) is a serine/threonine kinase that is related to the dual specific mitogen-activated protein kinase (MAPKK). The kinase is up-regulated in a variety of hematological malignancies, participates in activating lymphoid cells, and supports testicular function (spermatogenesis). Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cancer/testis antigen 84; CT84; epididymis luminal protein 164; Lymphokine-activated killer T-cell-originated protein kinase; MAPKK-like protein kinase; Nori-3; PDZ-binding kinase; serine/threonine protein kinase; Spermatogenesis-related protein kinase; SPK; T-LAK cell-originated protein kinase
基因别名: 2810434B10Rik; AW538537; CT84; D14Ertd732e; HEL164; Nori-3; PBK; SPK; TOPK
UniProt ID: (Human) Q96KB5, (Mouse) Q9JJ78
Entrez Gene ID: (Human) 55872, (Mouse) 52033, (Rat) 290326
protein phosphorylation
mitotic nuclear division
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of stress-activated MAPK cascade
cellular response to UV
negative regulation of inflammatory response
negative regulation of protein phosphorylation
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
