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PC1/3 Antibody (PA5-79787) in IHC (P)
Immunohistochemical analysis of PC1/3/PCSK1 in paraffin-embedded section of human colon cancer tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1μg/mL rabbit anti-PC1/3/PCSK1 antibody (Product # PA5-79787) overnight at 4°C. Biotin conjugated go... View More
产品信息
PA5-79787
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human PC1/3 (726-740aa DVFYNTKPYKHRDDR).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2746902
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
PCSK1 (Proprotein Convertase, Subtilisin/Kexin-Type, 1), also known as PC1 or NEC1, is an enzyme that in humans is encoded by the PCSK1 gene. Proprotein convertase-1 is a neuroendocrine convertase that belongs to a family of subtilisin-like serine endoproteases that process large precursor proteins into mature bioactive products. By in situ hybridization, Seidah et al. (1991) mapped the NEC1 gene to human chromosome 5q15-q21 and mouse chromosome 13. Ohagi et al. (1996) noted that PC1 initiates the sequential processing of proinsulin to insulin by cleaving the proinsulin molecule on the C-terminal side of the dibasic peptide, arg31-arg32, joining the B-chain and C-peptide. By observing the phenotypic features in patients with PC1 mutations, Jackson et al. (2003) concluded that human intestinal absorptive function is dependent on PC1 activity.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Furin homolog; NEC 1; Neuroendocrine convertase 1; PC1; PC3; Prohormone convertase 1; prohormone convertase 1/3; prohormone convertase 3; Propeptide-processing protease; Proprotein convertase 1; Protein convertase subtilisin / kexin type I; Protein convertase subtilisin / kexin, type I
基因别名: Att-1; BDP; BMIQ12; Nec-1; NEC1; PC1; PC3; PCSK1; Phpp-1; SPC3
UniProt ID: (Human) P29120, (Rat) P28840, (Mouse) P63239
Entrez Gene ID: (Human) 5122, (Rat) 25204, (Mouse) 18548
proteolysis
cell-cell signaling
metabolic process
protein processing
peptide hormone processing
peptide biosynthetic process
response to glucose
response to inorganic substance
response to chlorate
response to organic cyclic compound
protein autoprocessing
pituitary gland development
neurogenesis
pancreas development
response to nutrient levels
response to lipopolysaccharide
response to drug
response to morphine
response to peptide hormone
response to axon injury
positive regulation of protein secretion
response to glucocorticoid
response to calcium ion
response to fatty acid
response to interleukin-1
