Product References
Interaction with ERp57 is required for progranulin protection against Type 2 Gaucher disease.
Bioscience trends
Liu Y,Zhao X,Jian J,Hasan S,Liu C
40-3400 was used in Western Blotting to report ERp57 as a previously unrecognized binding partner of PGRN that contributes to PGRN regulation of GD.
Mon May 15 00:00:00 UTC 2023
Analysis of the Biomarkers for Neurodegenerative Diseases in Aged Progranulin Deficient Mice.
International journal of molecular sciences
Zhao X,Hasan S,Liou B,Lin Y,Sun Y,Liu C
40-3400 was used in Immunohistochemistry to suggest that PGRN plays an important role during the development of neurodegenerative disease, indicating that PGRN might be a useful biomarker for neurodegenerative diseases in clinical settings.
Thu Jan 06 00:00:00 UTC 2022
Progranulin associates with Rab2 and is involved in autophagosome-lysosome fusion in Gaucher disease.
Journal of molecular medicine (Berlin, Germany)
Zhao X,Liberti R,Jian J,Fu W,Hettinghouse A,Sun Y,Liu CJ
40-3400 was used in Western Blot to provide new insights into autophagy and may develop novel therapy for GD.
Mon Nov 01 00:00:00 UTC 2021
Progranulin Adsorbs to Polypropylene Tubes and Disrupts Functional Assays: Implications for Research, Biomarker Studies, and Therapeutics.
Frontiers in neuroscience
Gururaj S,Sampognaro PJ,Argouarch AR,Kao AW
40-3400 was used in Western Blotting to quantify the extent of rhPGRN adsorption to PPE tubes while varying experimental conditions, including incubation time and temperature.
Fri Nov 05 00:00:00 UTC 2021
Progranulin Adsorbs to Polypropylene Tubes and Disrupts Functional Assays: Implications for Research, Biomarker Studies, and Therapeutics.
Frontiers in neuroscience
Gururaj S,Sampognaro PJ,Argouarch AR,Kao AW
40-3400 was used in Western Blotting to quantify the extent of rhPGRN adsorption to PPE tubes while varying experimental conditions, including incubation time and temperature.
Fri Nov 05 00:00:00 UTC 2021
Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations.
Acta neuropathologica communications
Arrant AE,Roth JR,Boyle NR,Kashyap SN,Hoffmann MQ,Murchison CF,Ramos EM,Nana AL,Spina S,Grinberg LT,Miller BL,Seeley WW,Roberson ED
40-3400 was used in Western Blotting to show that progranulin insufficiency impairs β-glucocerebrosidase activity in the brain.
Mon Dec 23 00:00:00 UTC 2019
Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations.
eNeuro
Holler CJ,Taylor G,Deng Q,Kukar T
Published figure using PCDGF polyclonal antibody (Product # 40-3400) in Western Blot
Thu May 03 00:00:00 UTC 2018
Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia.
Cell chemical biology
She A,Kurtser I,Reis SA,Hennig K,Lai J,Lang A,Zhao WN,Mazitschek R,Dickerson BC,Herz J,Haggarty SJ
40-3400 was used in Western Blotting to demonstrate that inhibition of class I histone deacetylases is sufficient to upregulate progranulin in human neurons.
Thu Jul 20 00:00:00 UTC 2017
The Lysosomal Trafficking Transmembrane Protein 106B Is Linked to Cell Death.
The Journal of biological chemistry
Suzuki H,Matsuoka M
403400 was used in western blot to elucidate the mechanisms of TMEM106B-induced death
Fri Oct 07 00:00:00 UTC 2016
The Lysosomal Trafficking Transmembrane Protein 106B Is Linked to Cell Death.
The Journal of biological chemistry
Suzuki H,Matsuoka M
403400 was used in western blot to elucidate the mechanisms of TMEM106B-induced death
Fri Oct 07 00:00:00 UTC 2016
Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines.
Cell reports
Henry CM,Sullivan GP,Clancy DM,Afonina IS,Kulms D,Martin SJ
40-3400 was used in Immunodepletion to identify neutrophil granule proteases as potent IL-36-activating enzymes, and study how neutrophils escalate inflammatory reactions.
Tue Feb 02 00:00:00 UTC 2016
Granulin, a novel STAT3-interacting protein, enhances STAT3 transcriptional function and correlates with poorer prognosis in breast cancer.
Genes & cancer
Yeh JE,Kreimer S,Walker SR,Emori MM,Krystal H,Richardson A,Ivanov AR,Frank DA
40-3400 was used in immunocytochemistry, immunoprecipitation, and western blot to identify novel STAT3-interacting proteins in breast cancer cells
Sun Mar 01 00:00:00 UTC 2015
Granulin, a novel STAT3-interacting protein, enhances STAT3 transcriptional function and correlates with poorer prognosis in breast cancer.
Genes & cancer
Yeh JE,Kreimer S,Walker SR,Emori MM,Krystal H,Richardson A,Ivanov AR,Frank DA
40-3400 was used in immunocytochemistry, immunoprecipitation, and western blot to identify novel STAT3-interacting proteins in breast cancer cells
Sun Mar 01 00:00:00 UTC 2015
Evidence of the innate antiviral and neuroprotective properties of progranulin.
PloS one
Suh HS,Lo Y,Choi N,Letendre S,Lee SC
40-3400 was used in western blot to examine the role of progranulin during HIV infection of the central nervous system.
Thu Jan 15 00:00:00 UTC 2015
Evidence of the innate antiviral and neuroprotective properties of progranulin.
PloS one
Suh HS,Lo Y,Choi N,Letendre S,Lee SC
40-3400 was used in western blot to examine the role of progranulin during HIV infection of the central nervous system.
Thu Jan 15 00:00:00 UTC 2015
Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Chen X,Chang J,Deng Q,Xu J,Nguyen TA,Martens LH,Cenik B,Taylor G,Hudson KF,Chung J,Yu K,Yu P,Herz J,Farese RV,Kukar T,Tansey MG
40-3400 was used in western blot to test if aberrant PGRN-TNFR interactions underlie the molecular basis for neuroinflammation.
Wed May 22 00:00:00 UTC 2013
Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin.
Journal of neurochemistry
Dormann D,Capell A,Carlson AM,Shankaran SS,Rodde R,Neumann M,Kremmer E,Matsuwaki T,Yamanouchi K,Nishihara M,Haass C
40-3400 was used in western blot to examine proteolysis of TAR DNA binding protein-43.
Sat Aug 01 00:00:00 UTC 2009
Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.
The Journal of biological chemistry
Shankaran SS,Capell A,Hruscha AT,Fellerer K,Neumann M,Schmid B,Haass C
Fri Jan 18 00:00:00 UTC 2008
Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.
The Journal of biological chemistry
Shankaran SS,Capell A,Hruscha AT,Fellerer K,Neumann M,Schmid B,Haass C
Fri Jan 18 00:00:00 UTC 2008
Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.
The Journal of biological chemistry
Shankaran SS,Capell A,Hruscha AT,Fellerer K,Neumann M,Schmid B,Haass C
Fri Jan 18 00:00:00 UTC 2008
Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.
The Journal of biological chemistry
Shankaran SS,Capell A,Hruscha AT,Fellerer K,Neumann M,Schmid B,Haass C
Fri Jan 18 00:00:00 UTC 2008
