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产品信息
PA5-20703
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 17 amino acid peptide near the amino terminus of human PCDH12.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11157057
产品详细信息
A suggested positive control is K562 cell lysate.
PA5-20703 can be used with blocking peptide PEP-0818.
靶标信息
Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules. Protocadherin 12 (PCDH12) was initially identified through PCR screening of mouse heart microvascular endothelial cell RNA; further experiments revealed its mRNA to be strongly expressed in highly vascularized organs such as lung and kidney, in addition to glycogen-rich trophoblasts in the placenta. PCDH12-null mice are viable and fertile, but show reduced placental and embryonic sizes when compared to wild-type mice. Further studies showed significant expression changes in 2, 289 genes, including those involved in tissue morphogenesis, angiogenesis, cell-matrix adhesion and migration, immune response and chromatin remodeling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: protocadherin 14; Protocadherin-12; Protocadherin-12, secreted form; Vascular cadherin-2; vascular endothelial cadherin 2; Vascular endothelial cadherin-2; VE-cad-2; VE-cadherin 2; VE-cadherin-2
基因别名: PCDH12; Pcdh14; UNQ395/PRO731; VE-cad-2; VE-cadherin-2; VECAD2
UniProt ID: (Human) Q9NPG4, (Mouse) O55134
Entrez Gene ID: (Human) 51294, (Rat) 116808, (Mouse) 53601
