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PCDH15 Antibody (PA5-116505) in WB
Western blot analysis of PCDH15 in extracts of various cell lines. Samples were incubated with PCDH15 Polyclonal antibody (Product # PA5-116505) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
产品信息
PA5-116505
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 160-400 of human PCDH15 (NP_0011362351)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2901136
产品详细信息
Positive Samples: SH-SY5Y, 293T, A-549, Raji, Mouse brain, Mouse liver, Mouse spleen, Rat brain, Rat liver
Immunogen sequence: TVNELTPVGT TIFTGFSGDN GATDIDDGPN GQIEYVIQYN PDDPTSNDTF EIPLMLTGNI VLRKRLNYED KTRYFVIIQA NDRAQNLNER RTTTTTLTVD VLDGDDLGPM FLPCVLVPNT RDCRPLTYQA AIPELRTPEE LNPIIVTPPI QAIDQDRNIQ PPSDRPGILY SILVGTPEDY PRFFHMHPRT AELSLLEPVN RDFHQKFDLV IKAEQDNGHP LPAFAGLHIE ILDENNQSPY F
靶标信息
PCDH15 is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. PCDH15 consists of a signal peptide, 11 extracellular calcium-binding domains, a transmembrane domain and a unique cytoplasmic domain. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene have been associated with hearing loss, which is consistent with its location at the Usher syndrome type 1F (USH1F) critical region on chromosome 10.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ames waltzer; cadherin-related family member 15; DKFZp667A1711; protocadherin 15 CD2; protocadherin 15 CD3 isoform; Protocadherin-15; protocadherin-related 15; RP11-449J3.2
基因别名: av; BB078305; CDHR15; DFNB23; ENSMUSG00000046980; Gm9815; nmf19; PCDH15; USH1F
UniProt ID: (Human) C6ZEF7, (Mouse) Q99PJ1
Entrez Gene ID: (Human) 65217, (Rat) 690865, (Mouse) 11994
homophilic cell adhesion via plasma membrane adhesion molecules
sensory perception of sound
photoreceptor cell maintenance
inner ear development
sensory perception of light stimulus
equilibrioception
startle response
morphogenesis of an epithelium
actin filament organization
visual perception
locomotory behavior
adult walking behavior
adult locomotory behavior
nonmotile primary cilium assembly
multicellular organism growth
auditory receptor cell differentiation
detection of mechanical stimulus involved in sensory perception of sound
detection of mechanical stimulus involved in equilibrioception
response to calcium ion
righting reflex
auditory receptor cell stereocilium organization
cell adhesion
inner ear receptor stereocilium organization
