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产品信息
PA5-110082
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 62-286 of human PCMT1 (NP_001238978.1).
偶联物
形式
Liquid
浓度
1.11 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2855493
产品详细信息
Immunogen sequence: KSGGASHSEL IHNLRKNGII KTDKVFEVML ATDRSHYAKC NPYMDSPQSI GFQATISAPH MHAYALELLF DQLHEGAKAL DVGSGSGILT ACFARMVGCT GKVIGIDHIK ELVDDSVNNV RKDDPTLLSS GRVQLVVGDG RMGYAEEAPY DAIHVGAAAP VVPQALIDQL KPGGRLILPV GPAGGNQMLE QYDKLQDGSI KMKPLMGVIY VPLTDKEKQW SRDEL
靶标信息
Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 2.1.1.77) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: L-isoaspartyl protein carboxyl methyltransferase; PIMT; protein carboxyl methyltransferase; Protein L-isoaspartyl/D-aspartyl methyltransferase; Protein-beta-aspartate methyltransferase; Protein-L-isoaspartate(D-aspartate) O-methyltransferase
基因别名: C79501; PCM; PCMT1; PIMT
UniProt ID: (Human) P22061, (Rat) P22062, (Mouse) P23506
Entrez Gene ID: (Human) 5110, (Rat) 25604, (Mouse) 18537
