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产品信息
PA1-057
产品规格
种属反应
Mouse
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues S(111) V Q K D S A L D L F N D P M W N(127) of mouse PC1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2158588
产品详细信息
PA1-057 detects prohormone convertase 1 (PC1) from mouse pituitary extract.
PA1-057 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~80 kDa protein representing PC1 from mouse pituitary extract.
The PA1-057 immunogen is a synthetic peptide corresponding to residues S(111) V Q K D S A L D L F N D P M W N(127) of mouse PC1. This sequence is 88% and 82% conserved bovine and rat, respectively. The PA1-057 immunizing peptide (Cat. # PEP-164) is available for use in neutralization and control experiments.
靶标信息
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: EC 3.4.21.93; Furin homolog; NEC 1; Neuroendocrine convertase 1; PC1; PC3; Prohormone convertase 1; prohormone convertase 1/3; Propeptide-processing protease; Proprotein convertase 1
基因别名: Att-1; Nec-1; Nec1; PC1; PC3; Pcsk1; Phpp-1; SPC3
UniProt ID: (Mouse) P63239
Entrez Gene ID: (Mouse) 18548
