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Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Rat, Bovine, Elephant, Horse, Rabbit (100%); Gibbon, Mouse, Dog, Panda, Pig (93%); Turkey, Chicken (86%).
Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K.
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: kexin-like protease PC7A; Paired basic amino acid cleaving enzyme 4; paired basic amino acid cleaving system 4; Proprotein convertase subtilisin/kexin type 6; SPC4; Subtilisin - like endoprotease; Subtilisin-like proprotein convertase 4; Subtilisin/kexin-like protease PACE4
基因别名: PACE4; PCSK6; SPC4
UniProt ID: (Human) P29122, (Rat) Q63415
Entrez Gene ID: (Human) 5046, (Horse) 100057677, (Rabbit) 100347173, (Rat) 25507