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产品信息
PA5-38046
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
14 amino acid peptide near the carboxy terminus of human PDCL3
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2554650
产品详细信息
A recommended positive control is human brain tissue lysate.
PDCL3 antibody is not expected to cross-react with other members of the PDCL protein family.
靶标信息
Phosducin-like proteins (PhLPs) are a conserved family of proteins with thioredoxin-like domains that were initially identified as modulators of G protein signaling. PDCL3 is highly homologous to PDCL and shares an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain. Along with the related protein PDCL2, PDCL3 interacts with the chaperonin CCT and modulates CCT-mediated actin and tubulin folding. Modulation of PDCL3 levels by MAPK phosphorylation and RhoA-dependent changes also promote cytoskeletal remodeling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HTPHLP; IAP-associated factor VIAF1; phosducin-like 3; Phosducin-like protein 3; PhPL3; VIAF-1; Viral IAP-associated factor 1
基因别名: 1110061A19Rik; C80025; HTPHLP; PDCL3; PHLP2A; PHLP3; VIAF; VIAF1
UniProt ID: (Human) Q9H2J4, (Rat) Q4KLJ8, (Mouse) Q8BVF2
Entrez Gene ID: (Human) 79031, (Rat) 316348, (Mouse) 68833
angiogenesis
positive regulation of endothelial cell proliferation
protein folding
apoptotic process
queuosine biosynthetic process
viral process
positive regulation of angiogenesis
regulation of peptidyl-tyrosine phosphorylation
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
