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产品信息
PA5-31293
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 547 and 779 of Human PDE10A
偶联物
形式
Liquid
浓度
1.97 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2548767
产品详细信息
Recommended positive controls: HCT116, mouse brain, rat brain, Myc-DDK-tagged PDE10A-transfected 293T.
Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (84%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Various cellular responses are regulated by the second messengers cAMP and cGMP. Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; dJ416F21.1 (phosphodiesterase 10A); dual-substrate cAMP and cGMP, cyclic nucleotide phosphodiesterase; FLJ11894; FLJ25677; PDE10A2 brain-specific isoform; phosphodiesterase 10A1 (PDE10A1); phosphodiesterase 10A7 (PDE10A7); testis-specific phosphodiesterase PDE10A2
基因别名: ADSD2; HSPDE10A; IOLOD; LINC00473; PDE10A; PDE10A19; Pde10a3
UniProt ID: (Human) Q9Y233, (Mouse) Q8CA95, (Rat) Q9QYJ6
Entrez Gene ID: (Human) 10846, (Mouse) 23984, (Rat) 63885
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
drug binding
cAMP binding
cGMP binding
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
nucleotide binding
catalytic activity
cyclic-nucleotide phosphodiesterase activity
phosphoric diester hydrolase activity
hydrolase activity
phosphodiesterase
