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Product Details
PA5-70211
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide corresponding to a region of rat PDE2A
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2691031
Product Specific Information
This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rat: 100%
Target Information
PDE2A (phosphodiesterase 2A) is a 100 kD cyclic nucleotide phosphodiesterase (PDE) and three isoforms of PDE2A have been reported (PDE2A1, PDE2A2 and PDE2A3) which arise from a single gene by alternative splicing events. PDE2A can degrade both cAMP and cGMP, but degrades cGMP with greater efficacy. PDE2A is expressed in a variety of tissue types, with greatest expression in the brain, where it is localized in the cerebellum and neocortex. PDE2A has been implicated in penile erectile dysfunction and in the regulation of fluid and inflammatory cell transport across the endothelial cell barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cGMP-dependent 3',5'-cyclic phosphodiesterase; CGS-PDE; cGSPDE; cyclic GMP stimulated phosphodiesterase; Cyclic GMP-stimulated phosphodiesterase
Gene Aliases: Pde2; Pde2a; Pde2a2
UniProt ID: (Rat) Q01062
Entrez Gene ID: (Rat) 81743
negative regulation of transcription from RNA polymerase II promoter
cAMP catabolic process
protein targeting to mitochondrion
metabolic process
positive regulation of gene expression
cAMP-mediated signaling
cGMP-mediated signaling
monocyte differentiation
negative regulation of cAMP biosynthetic process
regulation of cGMP metabolic process
negative regulation of protein import into nucleus, translocation
cellular response to drug
cellular response to macrophage colony-stimulating factor stimulus
negative regulation of vascular permeability
positive regulation of vascular permeability
cGMP catabolic process
positive regulation of inflammatory response
establishment of endothelial barrier
cellular response to mechanical stimulus
cellular response to cGMP
cellular response to transforming growth factor beta stimulus
cellular response to granulocyte macrophage colony-stimulating factor stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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